ArticleMolecular microbiology2002
A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1.
Article in Molecular microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 55 citations in OpenAlex.
- The yeast two-component SLN1 branch of the HOG pathway and the scaffolding activity of Pbs2 modulate the response to endoplasmic reticulum stress induced by tunicamycin.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Design, characterization and in vivo functioning of a light-dependent histidine protein kinase in the yeast Saccharomyces cerevisiae.AMB Express · 2018Article
- Functional Divergence of Poplar Histidine-Aspartate Kinase HK1 Paralogs in Response to Osmotic Stress.International journal of molecular sciences · 2016Article
- Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae.BMC systems biology · 2015Article
- Information processing in the adaptation of Saccharomyces cerevisiae to osmotic stress: an analysis of the phosphorelay system.Systems and synthetic biology · 2014Article
- Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction.Open biology · 2014Article
- Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis.Frontiers in plant science · 2014Article
- Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants.BMC microbiology · 2013Article
- The MORC family: new epigenetic regulators of transcription and DNA damage response.Epigenetics · 2013Article
- Article
- Sphingolipids regulate the yeast high-osmolarity glycerol response pathway.Molecular and cellular biology · 2012Article
- The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter.The Journal of biological chemistry · 2012Article
- A framework for mapping, visualisation and automatic model creation of signal-transduction networks.Molecular systems biology · 2012Article
- Interactions among HAMP domain repeats act as an osmosensing molecular switch in group III hybrid histidine kinases from fungi.The Journal of biological chemistry · 2010Article
- The S helix mediates signal transmission as a HAMP domain coiled-coil extension in the NarX nitrate sensor from Escherichia coli K-12.Journal of bacteriology · 2010Article
- Genetic and biochemical analysis of the SLN1 pathway in Saccharomyces cerevisiae.Methods in enzymology · 2010Article
- Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC.Molecular microbiology · 2009Article
- Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans.Eukaryotic cell · 2009Article
- A unique GTP-dependent sporulation sensor histidine kinase in Bacillus anthracis.Journal of bacteriology · 2009Article
- Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The yeast histidine kinase, Sln1p, is a plasma membrane-associated osmosensor that regulates the activity of the osmotic stress MAP kinase pathway. Changes in the osmotic environment of the cell influence the autokinase activity of the cytoplasmic kinase domain of Sln1p. Neither the nature of the stimulus, the mechanism by which the osmotic signal is transduced nor the manner in which the kinase is regulated is currently clear. We have identified several mutations located in the linker region of the Sln1 kinase (just upstream of the kinase domain) that cause hyperactivity of the Sln1 kinase. This region of histidine kinases is largely uncharacterized, but its location between the transmembrane domains and the cytoplasmic kinase domain suggests that it may have a potential role in signal transduction. In this study, we have investigated the Sln1 linker region in order to understand its function in signal transduction and regulation of Sln1 kinase activity. Our results indicate that the linker region forms a coiled-coil structure and suggest a mechanism by which alterations induced by osmotic stress influence kinase activity by altering the alignment of the phospho-accepting histidine with respect to the catalytic domain of the kinase.
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