ArticleClinical and experimental immunology2002
Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Pooled it
- The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis.PloS one · 2013Pooled it
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Association of TLR4 Polymorphisms, Expression, and Vitamin D with Helicobacter pylori Infection.Journal of personalized medicine · 2019Article
- Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study.Scientific reports · 2018Article
- Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk.Asian Pacific journal of tropical medicine · 2016Article
- Association between CD14 SNP -159 C/T and gastric cancer: an independent case-control study and an updated meta-analysis.OncoTargets and therapy · 2016Article
- Gene polymorphisms associated with functional dyspepsia.World journal of gastroenterology · 2015Review
- Pattern-recognition receptors and gastric cancer.Frontiers in immunology · 2014Review
- Helicobacter pylori Infection Enhances Gastric Mucosal Inflammation in Individuals Carrying the 260-T Allele of the CD14 Gene.Gut and liver · 2013Article
- Association of CD14-260 polymorphisms, red-complex periodontopathogens and gingival crevicular fluid cytokine levels with cyclosporine A-induced gingival overgrowth in renal transplant patients.Journal of periodontal research · 2013Article
- The -159C/T polymorphism in the CD14 gene and cancer risk: a meta-analysis.OncoTargets and therapy · 2013Article
- CD14 promoter-159 polymorphism is associated with reduced risk of intestinal-type gastric cancer in a Japanese population.Digestive diseases and sciences · 2009Article
- A Genetic Variant of the CD14 C-159T in Patients with Functional Dyspepsia (FD) in Japanese Subjects.Journal of clinical biochemistry and nutrition · 2008Article
- Soluble CD14: role in atopic disease and recurrent infections, including otitis media.Current allergy and asthma reports · 2007Review
- Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.Digestive diseases and sciences · 2007Article
- Absence of Common Polymorphisms of Toll Like Receptor 4 (TLR4): Asp299Gly, Thr399Ile in Patients with Gastroduodenal Diseases in Japan.Journal of clinical biochemistry and nutrition · 2007Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Membrane-anchored CD14 is important for induction of interleukin-8 by lipopolysaccharide and peptidoglycan in uroepithelial cells.Clinical and diagnostic laboratory immunology · 2004Article
- A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNF alpha production.Genes and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD14 is a pattern recognition receptor on the membranes of monocytes and macrophages for several microbial products, of which lipopolysaccharide (LPS) is the best known. A shed form of CD14 is present in serum. As the CD14 gene promoter polymorphism -159C/T and some bacterial infections may affect the sCD14 levels, we compared the impact of both the CD14 promoter polymorphism and Helicobacter pylori infection on serum sCD14 levels in 201 dyspeptic patients (group 1) who had undergone gastroscopy, and 127 staff members (group 2) with no endoscopy. sCD14 was measured from the sera by a commercial enzyme immunoassay (EIA), and CD14 genotyping was carried out with PCR. Helicobacter pylori infection was detected by serology and/or culture or PCR. sCD14 levels were elevated in the subjects carrying the T allele (CT or TT genotype) in both groups when compared with subjects with the CC genotype. Overall, H. pylori-positive subjects tended to have higher sCD14 levels compared with H. pylori-negative subjects. In group 1 consisting of dyspeptic patients, those with gastric ulcer, gastric erosion or duodenal ulcer had significantly elevated levels of sCD14 compared with the patients with normal endoscopic findings or macroscopic gastritis. The recent use of NSAIDs was also associated with enhanced sCD14. Thus, we were able to show several factors, one genetic and the other environmental (H. pylori infection and mucosal lesion), to have an impact on sCD14.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.