ArticleProceedings of the National Academy of Sciences of the United States of America2002
Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 162 citations in OpenAlex.
- The Immune Microenvironment of Transplant Glomerulitis.Kidney international reports · 2025Article
- Best practices of heart transplantation in mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Review
- Surveillance and prevention of infection in clinical xenotransplantation.Clinical microbiology reviews · 2025Review
- Immunotherapy and Liver Transplantation: A Narrative Review of Basic and Clinical Data.Cancers · 2023Review
- Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15.Science immunology · 2023Article
- Treg suppression of immunity within inflamed allogeneic grafts.JCI insight · 2022Article
- Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.JCI insight · 2022Article
- Toward an understanding of allogeneic conflict in pregnancy and transplantation.The Journal of experimental medicine · 2022Review
- Resident memory T cells form during persistent antigen exposure leading to allograft rejection.Science immunology · 2021Article
- Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation.Science translational medicine · 2021Article
- Analysis of T-Cell Receptor Repertoire in Transplantation: Fingerprint of T Cell-mediated Alloresponse.Frontiers in immunology · 2021Review
- Dendritic Cells: Versatile Players in Renal Transplantation.Frontiers in immunology · 2021Review
- Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts.The Journal of clinical investigation · 2020Article
- Siplizumab, an Anti-CD2 Monoclonal Antibody, Induces a Unique Set of Immune Modulatory Effects Compared to Alemtuzumab and Rabbit Anti-Thymocyte GlobulinFrontiers in immunology · 2020Article
- Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Characterization of eomesodermin and T-bet expression by allostimulated CD8Clinical and experimental immunology · 2018Article
- Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection.Journal of the American Society of Nephrology : JASN · 2018Article
- Alloimmunity But Not Viral Immunity Promotes Allograft Loss in a Mouse Model of Polyomavirus-Associated Allograft Injury.Transplantation direct · 2017Article
- CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients.JCI insight · 2017Article
- Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective.Stem cells translational medicine · 2017Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The allospecifc T cell population responding to a transplanted organ consists of both naive and memory lymphocytes. Although it is established that naive T cells are activated by antigen within the organized structures of secondary lymphoid organs (the spleen, lymph nodes, and mucosal lymphoid tissues), it is not clear whether memory T cell activation and propagation depend on homing to these organs. To answer this question, we investigated whether allospecific naive or memory T cells can mediate acute cardiac allograft rejection in mutant mice that lack all of their secondary lymphoid tissues. The results of our experiments demonstrated that antigen-experienced memory T cells have two advantages over naive T cells: (i) memory T cells mount a vigorous immune response that leads to allograft rejection independent of secondary lymphoid organs; and (ii) memory T cells generate more memory T cells without homing to secondary lymphoid organs. These unique properties of memory T cells were further confirmed by showing that memory-like T cells that arise from the homeostatic proliferation of naive T cells in the absence of antigenic stimulation are suboptimal at rejecting allografts and do not generate memory T cells in mice devoid of secondary lymphoid tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.