ArticleProceedings of the National Academy of Sciences of the United States of America2002
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
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- Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration.Journal of cardiovascular development and disease · 2021Review
- Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements.Nucleic acids research · 2016Article
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- The whole-organism heavy chain B cell repertoire from Zebrafish self-organizes into distinct network features.BMC systems biology · 2011Article
- Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix.BMC evolutionary biology · 2009Article
- Establishment of the expression system for studying the function of active caspase-3 in zebrafish.Molecular biology reports · 2009Article
- Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish.Immunogenetics · 2008Article
- Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.PloS one · 2008Article
- Linkage maps for the Pacific abalone (genus Haliotis) based on microsatellite DNA markers.Genetics · 2007Article
- Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.Experimental hematology · 2007Article
- Insertional mutagenesis strategies in zebrafish.Genome biology · 2007Review
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- tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Hematopoietic gene expression profile in zebrafish kidney marrow.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Genome duplication, a trait shared by 22000 species of ray-finned fish.Genome research · 2003Article
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9 authors.
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Abstract
Recurring interstitial loss of all or part of the long arm of chromosome 5, del(5q), is a hallmark of myelodysplastic syndrome and acute myeloid leukemia. Although the genes affected by these changes have not been identified, two critically deleted regions (CDRs) are well established. We have identified 76 zebrafish cDNAs orthologous to genes located in these 5q CDRs. Radiation hybrid mapping revealed that 33 of the 76 zebrafish orthologs are clustered in a genomic region on linkage group 14 (LG14). Fifteen others are located on LG21, and two on LG10. Although there are large blocks of conserved syntenies, the gene order between human and zebrafish is extensively inverted and transposed. Thus, intrachromosomal rearrangements and inversions appear to have occurred more frequently than translocations during evolution from a common chordate ancestor. Interestingly, of the 33 orthologs located on LG14, three have duplicates on LG21, suggesting that the duplication event occurred early in the evolution of teleosts. Murine orthologs of human 5q CDR genes are distributed among three chromosomes, 18, 11, and 13. The order of genes within the three syntenic mouse chromosomes appears to be more colinear with the human order, suggesting that translocations occurred more frequently than inversions during mammalian evolution. Our comparative map should enhance understanding of the evolution of the del(5q) chromosomal region. Mutant fish harboring deletions affecting the 5q CDR syntenic region may provide useful animal models for investigating the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia.
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