ArticleClinical and experimental immunology2002
Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Intestinal failure from thymoma-associated autoimmune enteropathy: a rare case report.Clinical journal of gastroenterology · 2025Article
- Clinical manifestations, diagnosis and long-term prognosis of adult autoimmune enteropathy: Experience from Peking Union Medical College Hospital.World journal of gastroenterology · 2024Article
- Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies.International journal of molecular sciences · 2021Article
- Acute Flare of Adult-Onset Autoimmune Enteropathy Associated With Cyclophosphamide.ACG case reports journal · 2021Article
- Autoimmune Enteropathy: An Updated Review with Special Focus on Stem Cell Transplant Therapy.Digestive diseases and sciences · 2019Review
- Coeliac disease: beyond genetic susceptibility and gluten. A narrative review.Annals of medicine · 2019Review
- Article
- Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx.Internal and emergency medicine · 2013Article
- Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet.Clinical and translational gastroenterology · 2012Article
- Mesenchymal stromal cell infusions as rescue therapy for corticosteroid-refractory adult autoimmune enteropathy.Mayo Clinic proceedings · 2012Article
- Autoimmune enteropathy associated with cessation of interferon-alpha therapy in chronic hepatitis C.Digestive diseases and sciences · 2010Article
- Adult autoimmune enteropathy: Mayo Clinic Rochester experience.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2007Article
- An approach to duodenal biopsies.Journal of clinical pathology · 2006Review
- Occurrence of overt celiac disease in the elderly following total thyroidectomy.Journal of endocrinological investigation · 2006Article
- Adult celiac disease and the severe "flat" small bowel biopsy lesion.Digestive diseases and sciences · 2004Review
- Celiac disease: a model autoimmune disease with gene therapy applications.Gene therapy · 2003Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since in coeliac disease mucosal flattening has been suggested to result from an increased enterocyte apoptosis triggered by Fas/Fas ligand system and perforin cytolytic granules, we looked for a similar mechanism in autoimmune enteropathy. Moreover, we tried to assess whether enterocyte autoantibodies, which are the hallmark of autoimmune enteropathy, may be involved in triggering enterocyte apoptosis in this condition. Immunohistochemical staining with anti-Fas, -FasL and -perforin MoAb, and TUNEL technique were applied on endoscopic duodenal biopsies of two autoimmune enteropathy patients, two untreated coeliac patients and two biopsied controls. Cytotoxicity assays were carried out by incubating peripheral blood mononuclear cells from a healthy subject (effectors) with enterocytes primed with patient or control sera (targets). In autoimmune enteropathy a large number of enterocytes were apoptotic, as in coeliac disease, whereas neither Fas/Fas ligand or perforin expressions were up-regulated. On the other hand, antibody-dependent cellular cytotoxicity assay revealed the ability of sera from patients with autoimmune enteropathy to mediate enterocyte death through apoptosis. These results point to enterocyte autoantibody-dependent cellular cytotoxicity as the prevalent mechanism of increased enterocyte apoptosis in autoimmune enteropathy but not in coeliac disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.