ArticleInternational journal of impotence research2002
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.
Article in International journal of impotence research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step.British journal of pharmacology · 2022Article
- Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases.Scientific reports · 2020Article
- Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain.FEBS letters · 2016Article
- Gas what: NO is not the only answer to sexual function.British journal of pharmacology · 2015Review
- Analysis of erectile responses to BAY 41-8543 and muscarinic receptor stimulation in the rat.The journal of sexual medicine · 2013Article
- In vitro and in vivo studies on the importance of the soluble guanylyl cyclase α1 subunit in penile erection.World journal of urology · 2010Article
- The future is today: emerging drugs for the treatment of erectile dysfunction.Expert opinion on emerging drugs · 2010Review
- A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.Advances in pharmacological sciences · 2010Article
- Review
- NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential.Nature reviews. Drug discovery · 2006Review
- In vitro models: research in physiology and pharmacology of the lower urinary tract.British journal of pharmacology · 2006Review
- [Therapy for organic erectile dysfunction].Der Urologe. Ausg. A · 2005Review
- Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility.International journal of impotence research · 2004Review
- [Therapy of erectile dysfunction in 2005].Der Urologe. Ausg. A · 2003Article
- A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction.International journal of impotence research · 2002Review
- Review
- Role of the soluble guanylyl cyclase alpha1-subunit in mice corpus cavernosum smooth muscle relaxation.International journal of impotence researchArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) activates corpus cavernosum smooth muscle soluble guanylate cyclase (sGC) and increases the synthesis of cGMP that results in smooth muscle relaxation and ultimately, penile erection. To characterize sGC and define the potential synergy between NO and the allosteric activator YC-1 in corpus cavernosum, rat sGC was activated by either sodium nitroprusside (SNP) or YC-1, and YC-1 potentiated the effects of SNP with a 200-fold activation of sGC. Both SNP and YC-1 decreased the Km and increased the Vmax. ODQ significantly inhibited sGC activated by SNP with IC50 of 0.5 nM, but did not affect the sGC activated by YC-1 as well as basal sGC activity. SNP and YC-1 synergistically increased intracellular cGMP levels in rabbit corpus cavernosum smooth muscle cell cultures. YC-1 significantly relaxed rabbit cavernosum tissue strips in organ baths with an EC50 of 8.4 microM. In the presence of L-nitroarginine methyl ester to block endogenous NO production, co-administration of SNP shifted the dose response of YC-1 to the left, showing the synergism of SNP and YC-1 in tissue strips. In view of the clinical efficacy of phosphodiesterase-5 inhibitors, activation of sGC may provide an alternative means for enhancing the activity of neurally derived NO during sexual stimulation in the corpus cavernosum, representing a novel approach for the treatment of erectile dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.