ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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Who cites it
49 citing papers in PubMed, 105 citations in OpenAlex.
- The Motor Neuromuscular Axis: The Overlooked Element of Developmental Programming in Diabetes and Metabolic Syndrome.International journal of molecular sciences · 2026Review
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.Frontiers in neuroscience · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
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- Neuregulin 1 Drives Morphological and Phenotypical Changes in C2C12 Myotubes: TowardsFrontiers in cell and developmental biology · 2021Article
- Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns.Science advances · 2019Article
- Article
- Role of muscle spindle feedback in regulating muscle activity strength during walking at different speed in mice.Journal of neurophysiology · 2018Article
- Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Article
- Dicer maintains the identity and function of proprioceptive sensory neurons.Journal of neurophysiology · 2017Article
- Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Intrinsic Axonal Growth and the Drive for Regeneration.Frontiers in neuroscience · 2016Review
- Article
- Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke.Brain : a journal of neurology · 2016Article
- Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations.The Journal of comparative neurology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ia afferents induce the formation of muscle spindles prenatally and maintain them postnatally. To address whether spindles, in turn, regulate the function of Ia afferents, we examined Egr3-null mutant mice (Egr3-/-), in which muscle spindles degenerate progressively after birth. Egr3-/- mice develop gait ataxia, scoliosis, resting tremors, and ptosis, suggesting a defect in proprioception. Despite the normal morphological appearance of peripheral and central sensory projections, we observed a profound functional deficit in the strength of sensory-motor connections in Egr3-/- mice. Muscle spindles in Egr3-/- mice do not express NT3. Intramuscular injections of NT3 to Egr3-/- mice during the postnatal period restored sensory-motor connections. Thus, NT3 derived from muscle spindles regulates the synaptic connectivity between muscle sensory and motor neurons.
Indexed as
Identifiers
11978828PMC6758400W2141484533What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.