ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 137 citations in OpenAlex.
- Hippocampal criticality tracks cognitive demand and shifts with memory impairment.Communications biology · 2026Article
- Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons.Biomolecules · 2024Review
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Mitochondrial Calcium Waves by Electrical Stimulation in Cultured Hippocampal Neurons.Molecular neurobiology · 2024Article
- Article
- Muscarinic acetylcholine receptor-dependent and NMDA receptor-dependent LTP and LTD share the common AMPAR trafficking pathway.iScience · 2023Article
- The interaction between hippocampal cholinergic and nitrergic neurotransmission coordinates NMDA-dependent behavior and autonomic changes induced by contextual fear retrieval.Psychopharmacology · 2022Article
- Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease.Archives of pharmacal research · 2021Review
- Scopolamine Impairs Spatial Information Recorded With "Miniscope" Calcium Imaging in Hippocampal Place Cells.Frontiers in neuroscience · 2021Article
- Intracellular Calcium Responses Encode Action Potential Firing in Spinal Cord Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity.Cold Spring Harbor perspectives in biology · 2020Review
- Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization.Neuroendocrinology · 2020Article
- A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity.Frontiers in computational neuroscience · 2020Article
- Review
- Article
- GPCR signalling from within the cell.British journal of pharmacology · 2018Review
- Calcium signalling in medial intercalated cell dendrites and spines.The Journal of physiology · 2017Article
- Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors.Frontiers in neural circuits · 2017Review
- The role of basal forebrain cholinergic neurons in fear and extinction memory.Neurobiology of learning and memory · 2016Review
- Early stress prevents the potentiation of muscarinic excitation by calcium release in adult prefrontal cortex.Biological psychiatry · 2014Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cholinergic system is thought to play an important role in hippocampal-dependent learning and memory. However, the mechanism of action of the cholinergic system in these actions in not well understood. Here we examined the effect of muscarinic receptor stimulation in hippocampal CA1 pyramidal neurons using whole-cell recordings in acute brain slices coupled with high-speed imaging of intracellular calcium. Activation of muscarinic acetylcholine receptors by synaptic stimulation of cholinergic afferents or application of muscarinic agonist in CA1 pyramidal neurons evoked a focal rise in free calcium in the apical dendrite that propagated as a wave into the soma and invaded the nucleus. The calcium rise to a single action potential was reduced during muscarinic stimulation. Conversely, the calcium rise during trains of action potentials was enhanced during muscarinic stimulation. The enhancement of free intracellular calcium was most pronounced in the soma and nuclear regions. In many cases, the calcium rise was distinguished by a clear inflection in the rising phase of the calcium transient, indicative of a regenerative response. Both calcium waves and the amplification of action potential-induced calcium transients were blocked the emptying of intracellular calcium stores or by antagonism of inositol 1,4,5-trisphosphate receptors with heparin or caffeine. Ryanodine receptors were not essential for the calcium waves or enhancement of calcium responses. Because rises in nuclear calcium are known to initiate the transcription of novel genes, we suggest that these actions of cholinergic stimulation may underlie its effects on learning and memory.
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Identifiers
11978822PMC6758367W1812636860What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.