ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Erg currents support electrical bursting in murine anterior pituitary corticotrophs.The Journal of physiology · 2026Article
- Calcium signaling properties of a thyrotroph cell line, mouse TαT1 cells.Cell calcium · 2015Article
- Scorpion venom components that affect ion-channels function.Toxicon : official journal of the International Society on Toxinology · 2013Review
- Ion channels and signaling in the pituitary gland.Endocrine reviews · 2010Review
- Erg K+ currents modulate excitability in mouse mitral/tufted neurons.Pflugers Archiv : European journal of physiology · 2009Article
- Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.The Journal of biological chemistry · 2009Article
- Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans.Neurochemical research · 2008Article
- Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging.Pflugers Archiv : European journal of physiology · 2008Article
- Ether-a-go-go-related gene potassium channels: what's all the buzz about?Schizophrenia bulletin · 2007Review
- Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling.Molecular biology of the cell · 2005Article
- Fast erg K+ currents in rat embryonic serotonergic neurones.The Journal of physiology · 2005Article
- Therapeutic potential of venom peptides.Nature reviews. Drug discovery · 2003Review
- BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1.Biophysical journal · 2003Article
- Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.The Journal of physiology · 2003Article
- Review
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Native rat lactotrophs express thyrotrophin-releasing hormone-dependent K+ currents consisting of fast and slow deactivating components that are both sensitive to the class III anti-arrhythmic drugs that block the eag-related gene (ERG) K+ current (I(ERG)). Here we describe in MMQ prolactin-releasing pituitary cells the isolation of the slowly deactivating long-lasting component (I(ERGS)), which, unlike the fast component (I(ERGF)), is insensitive to verapamil 2 microm but sensitive to a novel scorpion toxin (ErgTx-2) that hardly affects I(ERGF). The time constants of I(ERGS) activation, deactivation, and recovery from inactivation are more than one order of magnitude greater than in I(ERGF), and the voltage-dependent inactivation is left-shifted by approximately 25 mV. The very slow MMQ firing frequency (approximately 0.2 Hz) investigated in perforated patch is increased approximately four times by anti-arrhythmic agents, by ErgTx-2, and by the abrupt I(ERGS) deactivation. Prolactin secretion in the presence of anti-arrhythmics is three- to fourfold higher in comparison with controls. We provide evidence from I(ERGS) and I(ERGF) simulations in a firing model cell to indicate that only I(ERGS) has an accommodating role during the experimentally observed very slow firing. Thus, we suggest that I(ERGS) potently modulates both firing and prolactin release in lactotroph cells.
Indexed as
Identifiers
11978818PMC6758369W1606051839What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.