ArticleArchives of disease in childhood. Fetal and neonatal edition2002
Magnetic resonance imaging of the infant brain: anatomical characteristics and clinical significance of punctate lesions.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 11 of them syntheses that pooled it.
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53 citing papers in PubMed, 11 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.PloS one · 2021Pooled it
- Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Confounding biases in studies on early- versus late-caffeine in preterm infants: a systematic review.Pediatric research · 2020Pooled it
- Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants.The Cochrane database of systematic reviews · 2020Pooled it
- Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular haemorrhage in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Stem cell-based interventions for the prevention and treatment of germinal matrix-intraventricular haemorrhage in preterm infants.The Cochrane database of systematic reviews · 2019Pooled it
- Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular hemorrhage in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Clonidine for sedation and analgesia for neonates receiving mechanical ventilation.The Cochrane database of systematic reviews · 2017Pooled it
- Heparin for the prevention of intraventricular haemorrhage in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- Optimal timing of cerebral MRI in preterm infants to predict long-term neurodevelopmental outcome: a systematic review.AJNR. American journal of neuroradiology · 2014Pooled it
- Seizures and Apneas as clinical manifestations of brain lesions in term infants: a single center experience.Italian journal of pediatrics · 2026Article
- Structural and functional connectivity of the brain in premature infants with non-hemorrhagic punctate white matter lesions: a graph analysis.Pediatric radiology · 2026Article
- Incidence and Risk Factors of White Matter Lesions in Moderate and Late Preterm Infants.Diagnostics (Basel, Switzerland) · 2025Article
- Cerebral Ultrasound at Term-Equivalent Age: Correlations with Neuro-Motor Outcomes at 12-24 Months Corrected Age.Children (Basel, Switzerland) · 2024Article
- Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Review
- Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity.The Cochrane database of systematic reviews · 2023Review
- Stem cell-based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Nosological Differences in the Nature of Punctate White Matter Lesions in Preterm Infants.Frontiers in neurology · 2021Article
- Association Between Assisted Reproductive Technology and White Matter Injury in Premature Infants: A Case-Control Study.Frontiers in pediatrics · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the magnetic resonance imaging (MRI) characteristics of punctate brain lesions in neonates (number, appearance, distribution, and association with other brain abnormalities) and to relate them to neurodevelopmental outcome.
methodsA retrospective analysis was performed of 110 MRI brain scans from 92 infants admitted in 1998 to the neonatal intensive care unit. Results of routine neurodevelopmental follow up (1998-2001) in those infants with punctate brain lesions were analysed.
resultsPunctate lesions were observed in 15/50 preterm and 2/42 term infants. In the preterm group, the number of lesions was < 3 in 20%, 3-10 in 27%, and > 10 in 53%. In 14/15 the lesions were linearly organised and located in the centrum semiovale. Other brain abnormalities were absent or minor--that is, "isolated" punctate lesions--in 8/15 and major in 7/15. In the term group, punctate lesions were organised in clusters and no other brain abnormalities were observed. Isolated punctate lesions were observed in 10/17 infants, and a normal neurodevelopmental outcome was seen in 9/10 (mean follow up 29.5 months). One infant showed a slight delay in language development. In the infants with associated brain lesions (7/17, mean follow up 27.5 months), outcome was normal in only two subjects.
conclusionsPunctate lesions are predominantly seen in preterm infants, are usually linearly organised, and border the lateral ventricles. Isolated punctate lesions may imply a good prognosis, because most of these subjects have a normal neurodevelopmental outcome so far.
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