ReviewClinical reviews in allergy & immunology2002
Mast cell growth, differentiation, and death.
Review in Clinical reviews in allergy & immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Mast cells: key players in digestive system tumors and their interactions with immune cells.Cell death discovery · 2025Review
- IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells.International journal of molecular sciences · 2023Article
- Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology.Biomedicines · 2021Review
- Review
- Assessment of faithful interleukin-3 production by novel bicistronic interleukin-3 reporter mice.Immunology letters · 2020Article
- Short-term in vitro culture of purity and highly functional rat bone marrow-derived mast cells.In vitro cellular & developmental biology. Animal · 2018Article
- Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats.Journal of pain research · 2018Article
- The role of mast cells in oral squamous cell carcinoma.Contemporary oncology (Poznan, Poland) · 2017Review
- Pros and Cons of Clinical Basophil Testing (BAT).Current allergy and asthma reports · 2016Review
- Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis.Scientific reports · 2015Article
- Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains.Inflammation · 2015Article
- Interleukin-3-deficient mice have increased resistance to blood-stage malaria.Infection and immunity · 2014Article
- Review
- Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Hematopoietic stem/precursor cells as HIV reservoirs.Current opinion in HIV and AIDS · 2011Review
- Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma.International journal of clinical and experimental pathology · 2010Article
- Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats.Radiation research · 2010Article
- Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.The Journal of experimental medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mast cells (MC) begin development in the bone marrow. Following initial lineage commitment, the cells move into the vasculature as a committed progenitor (MCp) that is poorly phenotypically defined, but appears to be an agranular cell lacking the high-affinity IgE receptor characteristic of the mature tissue-localized MC. Full maturation occurs after the cells move into the various tissues. In the mouse, MCp localizing in the connective tissues appear to differentiate into mature MC, whereas those localizing in the lung and mucosal compartment of the small intestine remain largely as committed MCp. Movement of the MCp into the small intestine is controlled by the alpha 4 beta 7 integrin, whereas the factors controlling movement into other tissues remain to be defined. Following an inflammatory stimulus, Th2-derived cytokines drive the maturation process of these MCps, leading to the mature mucosal MC hyperplasia associated with events such as an intestinal helminth infection and possibly human allergy such as asthma and rhinitis. The expanded MC number disappears as the stimulus resolves. Various routes are used in the resolution of the MC hyperplasia including apoptosis, shedding along with the villous epithelium, and recirculation back to the spleen for elimination. Unlike the reactive MC that appears in association with inflammation, the connective tissue-localized MC is a long-lived radiation-resistant cell, which appears to depend principally on the presence of stem cell factor (SCF) for its persistence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.