ArticleOncogene2002
Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Anoikis: To Die or Not to Die?International journal of molecular sciences · 2026Review
- Anoikis resistance and cancer.BMC cancer · 2025Review
- Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.Journal of virology · 2017Article
- Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.Molecular biology of the cell · 2016Article
- Anoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists.Oncogene · 2015Article
- Article
- Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression.Nature reviews. Cancer · 2014Review
- Uncovering a key to the process of metastasis in human cancers: a review of critical regulators of anoikis.Journal of cancer research and clinical oncology · 2013Review
- ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.The Journal of biological chemistry · 2013Article
- Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner.Carcinogenesis · 2012Article
- Pleiotropic action of AP-1 in v-Src-transformed cells.Journal of virology · 2011Article
- Significance of talin in cancer progression and metastasis.International review of cell and molecular biology · 2011Review
- Apoptosis and inflammation: role of adipokines in inflammatory bowel disease.Clinical and translational gastroenterology · 2010Article
- Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.The Journal of biological chemistry · 2009Article
- Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival.Regulatory peptides · 2009Article
- Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells.World journal of gastroenterology · 2008Article
- Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer.Clinical & experimental metastasis · 2008Article
- Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis.Cancer research · 2007Article
- Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3.The Biochemical journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquisition of resistance to anoikis (detachment-induced apoptosis) is considered to be a requirement for transformed intestinal epithelial cells to invade surrounding tissues and metastasize to distant organs. Increased Src kinase activity, which is a feature of a large proportion of colorectal cancers, has been identified as one of the factors that can contribute to anoikis resistance. However, the molecular mechanism by which high levels of Src activity contribute to anoikis resistance in intestinal epithelial cells is unknown. Here we show that high Src activity confers resistance to anoikis in intestinal epithelial cells, at least in part, by inducing Bcl-xL overexpression, and that this induction is mediated by the MEK/MAPK pathway. Based on the findings reported here, and on our previous study showing that Bcl-xL plays a critical role in ras-induced resistance to anoikis, we propose that the increased Bcl-xL levels found in colorectal cancers play a significant role in the induction of resistance to anoikis during the progression of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.