ArticleOncogene2002
Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- GEFT Inhibits Autophagy and Apoptosis in RhabdomyosarcomaFrontiers in oncology · 2021Article
- DEPDC1B is a key regulator of myoblast proliferation in mouse and man.Cell proliferation · 2020Article
- Shisa2 regulates the fusion of muscle progenitors.Stem cell research · 2018Article
- P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.The Journal of cell biology · 2016Article
- Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Myoblasts and macrophages share molecular components that contribute to cell-cell fusion.The Journal of cell biology · 2008Article
- RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth.The American journal of pathology · 2007Article
- M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.Molecular biology of the cell · 2007Article
- Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.Neoplasia (New York, N.Y.) · 2006Article
- Transforming growth factor beta induces rosettes of podosomes in primary aortic endothelial cells.Molecular and cellular biology · 2006Article
- Article
- Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma.Oncogene · 2004Article
- Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells.Molecular and cellular biology · 2003Article
- N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.The Journal of cell biology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that expression of active Rac1 and Cdc4Hs inhibits skeletal muscle cell differentiation. We show here, by bromodeoxyuridine incorporation and cyclin D1 expression, that the expression of active Rac1 and Cdc42Hs but not RhoA impairs cell cycle exit of L6 myoblasts cultured in differentiation medium. Furthermore, expression of activated forms of Rac1 and Cdc42Hs elicits the loss of cell contact inhibition and anchorage-dependent growth as measured by focus forming activity and growth in soft agar. RhoA was once again not found to have this effect. We found a constitutive Rac1 and Cdc42Hs activation in three human rhabdomyosarcoma-derived cell lines, one of the most common causes of solid tumours arising from muscle precursors during childhood. Finally, dominant negative forms of Rac1 and Cdc42Hs inhibit cell proliferation of the RD rhabdomyosarcoma cell line. These data suggest an important role for the small GTPases Rac1 and Cdc42Hs in the generation of skeletal muscle tumours.
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Registered trials
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