ArticleGenetics2002
Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Glycogen synthase activity inmSphere · 2024Article
- Article
- The distribution of beneficial mutational effects between two sister yeast species poorly explains natural outcomes of vineyard adaptation.bioRxiv : the preprint server for biology · 2024Article
- Phosphoregulation of the yeast Pma1 H+-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control.PLoS genetics · 2024Article
- The phosphatase Glc7 controls the eisosomal response to starvation via post-translational modification of Pil1.Journal of cell science · 2023Article
- Abscisic Acid, Stress, and Ripening (BioMed research international · 2020Article
- Ser/Thr protein phosphatases in fungi: structure, regulation and function.Microbial cell (Graz, Austria) · 2019Review
- Glc8, a regulator of protein phosphatase type 1, mediates oxidation tolerance, asexual development and virulence in Beauveria bassiana, a filamentous entomopathogenic fungus.Current genetics · 2019Article
- Compensatory Internalization of Pma1 in V-ATPase Mutants inGenetics · 2018Article
- Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling.BMC genomics · 2017Article
- Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases.PLoS genetics · 2016Article
- Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response.BMC genomics · 2015Article
- Transcriptional profile of Paracoccidioides induced by oenothein B, a potential antifungal agent from the Brazilian Cerrado plant Eugenia uniflora.BMC microbiology · 2013Article
- Regulation of cation balance in Saccharomyces cerevisiae.Genetics · 2013Review
- Functional analyses of NSF1 in wine yeast using interconnected correlation clustering and molecular analyses.PloS one · 2013Article
- Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast.Cell research · 2012Article
- Article
- The effect of a genetically reduced plasma membrane protonmotive force on vegetative growth of Arabidopsis.Plant physiology · 2012Article
- Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae.Molecular biology of the cell · 2008Article
- Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Protein phosphatase type 1 (PP1) is encoded by the essential gene GLC7 in Saccharomyces cerevisiae. glc7-109 (K259A, R260A) has a dominant, hyperglycogen defect and a recessive, ion and drug sensitivity. Surprisingly, the hyperglycogen phenotype is partially retained in null mutants of GAC1, GIP2, and PIG1, which encode potential glycogen-targeting subunits of Glc7. The R260A substitution in GLC7 is responsible for the dominant and recessive traits of glc7-109. Another mutation at this residue, glc7-R260P, confers only salt sensitivity, indicating that the glycogen and salt traits of glc7-109 are due to defects in distinct physiological pathways. The glc7-109 mutant is sensitive to cations, aminoglycosides, and alkaline pH and exhibits increased rates of l-leucine and 3,3'-dihexyloxacarbocyanine iodide uptake, but it is resistant to molar concentrations of sorbitol or KCl, indicating that it has normal osmoregulation. KCl suppresses the ion and drug sensitivities of the glc7-109 mutant. The CsCl sensitivity of this mutant is suppressed by recessive mutations in PMA1, which encodes the essential plasma membrane H(+)ATPase. Together, these results indicate that Glc7 regulates ion homeostasis by controlling ion transport and/or plasma membrane potential, a new role for Glc7 in budding yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.