ArticleGenetics2002
Domains of gene silencing near the left end of chromosome III in Saccharomyces cerevisiae.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading.Nucleic acids research · 2022Article
- Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions.Genome research · 2018Article
- Single cell visualization of yeast gene expression shows correlation of epigenetic switching between multiple heterochromatic regions through multiple generations.PLoS biology · 2013Article
- The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state.PLoS computational biology · 2013Article
- Review
- Principles of chromosomal organization: lessons from yeast.The Journal of cell biology · 2011Review
- Article
- DNA polymerase epsilon, acetylases and remodellers cooperate to form a specialized chromatin structure at a tRNA insulator.The EMBO journal · 2009Article
- Assembling heterochromatin in the appropriate places: A boost is needed.Journal of cellular physiology · 2009Review
- Limiting the extent of the RDN1 heterochromatin domain by a silencing barrier and Sir2 protein levels in Saccharomyces cerevisiae.Molecular and cellular biology · 2009Article
- The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.Genome research · 2009Article
- Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.Molecular cell · 2007Article
- Mutations in the nucleosome core enhance transcriptional silencing.Molecular and cellular biology · 2005Article
- Molecular requirements for gene expression mediated by targeted histone acetyltransferases.Molecular and cellular biology · 2004Article
- Barrier proteins remodel and modify chromatin to restrict silenced domains.Molecular and cellular biology · 2004Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
In Saccharomyces cerevisiae the HM loci and regions adjacent to the telomeres are transcriptionally silent. HML is situated 11 kb from the left telomere of chromosome III. I have systematically examined gene silencing along this 11-kb chromosomal region. I found that silencing extends at least 1.1 kb beyond HML, indicating that the HML E silencer acts on both sides. Moreover, I obtained evidence indicating that a 0.71-kb sequence near the E silencer acts as a barrier to the spread of silencing and coincides with the left boundary of the silent HML domain. I also showed that silencing at the telomere is limited to an approximately 2-kb domain. On the other hand, an approximately 7-kb region between HML and the telomere is not silenced by HML or the telomere. These results provide a clear example of organization of the eukaryotic genome into interspersed domains with distinct potentials for gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.