ArticleNucleic acids research2002
Heterogeneity in the rate and pattern of germline mutation at individual microsatellite loci.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 90 citations in OpenAlex.
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- Maintenance of Genetic Diversity Despite Population Fluctuations in the Lesser Prairie-Chicken (Ecology and evolution · 2025Article
- Untangling the hedge: Genetic diversity in clonally and sexually transmitted genomes of European wild roses, Rosa L.PloS one · 2023Article
- Species-landscape interactions drive divergent population trajectories in four forest-dependent Afromontane forest songbird species within a biodiversity hotspot in South Africa.Evolutionary applications · 2021Article
- Massively parallel sequencing and capillary electrophoresis of a novel panel of falcon STRs: Concordance with minisatellite DNA profiles from historical wildlife crime.Forensic science international. Genetics · 2021Article
- Past and Recent Effects of Livestock Activity on the Genetic Diversity and Population Structure of Native Guanaco Populations of Arid Patagonia.Animals : an open access journal from MDPI · 2021Article
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- Phylogeography and Population Genetics ofFrontiers in genetics · 2019Article
- Genetic variation in nuclear and mitochondrial markers supports a large sex difference in lifetime reproductive skew in a lekking species.Ecology and evolution · 2014Article
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- A versatile microsatellite instability reporter system in human cells.Nucleic acids research · 2013Article
- Breakdown of phylogenetic signal: a survey of microsatellite densities in 454 shotgun sequences from 154 non model eukaryote species.PloS one · 2012Article
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- Age before beauty? Relationships between fertilization success and age-dependent ornaments in barn swallows.Behavioral ecology and sociobiology · 2011Article
- Perspective on sequence evolution of microsatellite locus (CCG)n in Rv0050 gene from Mycobacterium tuberculosis.BMC evolutionary biology · 2011Article
- Evidence for heterozygote instability in microsatellite loci in house wrens.Biology letters · 2011Article
- Determining microsatellite genotyping reliability and mutation detection ability: an approach using small-pool PCR from sperm DNA.Molecular genetics and genomics : MGG · 2011Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- Microsatellite mutation rates in the eastern tiger salamander (Ambystoma tigrinum tigrinum) differ 10-fold across loci.Genetica · 2009Article
- Experimental estimation of mutation rates in a wheat population with a gene genealogy approach.Genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a lack of information on how individual microsatellite loci differ with respect to their mutation properties. Such variation will have an important bearing on our understanding of the ubiquitous occurrence of simple repeat sequences in eukaryotic genomes and on deriving proper mutation models that can be incorporated into genetic distance estimates. We genotyped approximately 100 families of the bird barn swallow (Hirundo rustica) for two hypervariable (heterozygosity >95%) microsatellite markers: HrU6, an (AAAG)n tetranucleotide repeat, and HrU10, an (AAGAG)n pentanucleotide repeat. A total of 27 germline mutation events were documented, corresponding to mutation rates of 0.57% (HrU6) and 1.56% (HrU10). The mutation rate increased with allele size, at approximately 0.1% per repeat unit over the observed range of allele sizes (approximately 10-100 repeat units). Single repeat unit changes dominated, with 21/27 mutations representing the gain or loss of one repeat unit. There was no clear difference in the number of gains versus losses nor was there an effect of allele size on the magnitude or direction of mutation. Unexpectedly, the mutation rate of females (maternally transmitted mutations) was 2.5-5 times higher than that of males. Contrasting these observations with mutation data from other microsatellite loci reveals differences not only in the mutation rate, but also in the magnitude, direction and effect of sex on mutation. Thus, microsatellite mutation and evolution may be viewed as a dynamic and variable process.
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