ArticleNucleic acids research2002
A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 46 citations in OpenAlex.
- BRCA1 and BRCA2 gene expression: p53- and cell cycle-dependent repression requires RB and DREAM.Cell death and differentiation · 2026Article
- Polyploid giant cancer cells and cancer progression.Frontiers in cell and developmental biology · 2022Review
- The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review.Cancer cell international · 2020Review
- Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM.Cell death and differentiation · 2018Review
- Article
- E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53.The Journal of biological chemistry · 2016Article
- Article
- Site-specific programming of the host epithelial transcriptome by the gut microbiota.Genome biology · 2015Article
- Article
- The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.Nucleic acids research · 2012Article
- The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene.Cell cycle (Georgetown, Tex.) · 2011Article
- Function of the A-type cyclins during gametogenesis and early embryogenesis.Results and problems in cell differentiation · 2011Review
- CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.Molecular and cellular biology · 2009Article
- Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site.Nucleic acids research · 2008Article
- Cloning of the black seabream (Acanthopagrus schlegeli) antiquitin gene and functional characterization of its promoter region.Molecular and cellular biochemistry · 2007Article
- Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest.The Biochemical journal · 2006Article
- The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.Molecular systems biology · 2005Article
- Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The cdc25C phosphatase participates in regulating transition from the G2 phase of the cell cycle to mitosis by dephosphorylating cyclin-dependent kinase 1. The tumor suppressor p53 down-regulates expression of cdc25C as part of G2/M checkpoint control. Transcription of cdc25C oscillates during the cell cycle with no expression in resting cells and maximum transcription in G2. We had identified earlier a new mechanism of cell cycle-dependent transcription that is regulated by a cell cycle-dependent element (CDE) in conjunction with a cell cycle genes homology region (CHR). The human cdc25C gene was the first example. CDE/CHR tandem elements have since been found in promoters of many cell cycle genes. Here we show that the mouse cdc25C gene is regulated by a CHR but does not hold a CDE. Therefore, it is the first identified gene with CHR-dependent transcriptional regulation during the cell cycle not relying on a CDE located upstream of it. The CHR leads to repression of cdc25C transcription early in the cell cycle and directs a release of this repression in G2. Furthermore, we find that this CHR can cooperate in cell cycle-dependent transcription with elements placed directly upstream of it binding E2F, Sp1 or Sp3 transcription factors.
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