ArticleNucleic acids research2002
S6 phosphorylation-independent pathways regulate translation of 5'-terminal oligopyrimidine tract-containing mRNAs in differentiating hematopoietic cells.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Protein phosphatase 2A propels follicular T helper cell development in lupus.Journal of autoimmunity · 2023Article
- mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.Nucleic acids research · 2021Article
- Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants.Plant physiology · 2018Review
- Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications.Medicinal research reviews · 2015Review
- Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.The Journal of biological chemistry · 2015Article
- Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- RNA binding protein/RNA element interactions and the control of translation.Current protein & peptide science · 2012Review
- AMPK represses TOP mRNA translation but not global protein synthesis in liver.Biochemical and biophysical research communications · 2008Article
- Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.Molecular and cellular biology · 2007Article
- Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases.Oncogene · 2006Review
- Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation.The Journal of nutrition · 2006Article
- Amino acids as regulators of gene expression.Nutrition & metabolism · 2004Article
- Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize.Plant physiology · 2003Article
- Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Synthesis of new ribosomes is an energy costly and thus highly regulated process. Ribosomal protein synthesis is controlled by regulating translation of the corresponding ribosomal protein (rp)mRNAs. In mammalian cells a 5'-terminal oligopyrimidine tract (TOP) is a conserved feature of these mRNAs that has been demonstrated to be essential for their translational regulation. Translation of TOP mRNAs has been proposed to be regulated by phosphorylation of ribosomal protein S6, which is a common effect of mitogenic stimulation of cells. However, as demonstrated here, S6 phosphorylation is not detectable in murine erythroleukemia (MEL) or other hematopoietic cells. The absence of S6 phosphorylation appears to be due to the action of a phosphatase that acts downstream of S6 kinase, presumably on S6 itself. Despite the absence of changes in S6 phosphorylation, translation of TOP mRNAs is repressed during differentiation of MEL cells. These data demonstrate the existence of a mechanism for regulating S6 phosphorylation that is distinct from kinase activation, as well as the existence of mechanisms for regulating translation of TOP mRNAs that are independent of S6 phosphorylation.
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Registered trials
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