ArticleProceedings of the National Academy of Sciences of the United States of America2002
Evolution of the RNA polymerase II C-terminal domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 84 citations in OpenAlex.
- Bridging single-molecule and genome-wide studies of cellular mRNA translation.RNA (New York, N.Y.) · 2026Review
- Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex.The Journal of biological chemistry · 2026Article
- Transcription activation depends on the length of the RNA polymerase II C-terminal domain.The EMBO journal · 2021Article
- A combinatorial view of old and new RNA polymerase II modifications.Transcription · 2020Review
- Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control.Wiley interdisciplinary reviews. RNA · 2019Review
- Localization of RNAPII and 3' end formation factor CstF subunits on C. elegans genes and operons.Transcription · 2016Article
- Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.BMC evolutionary biology · 2015Article
- Evolutionary diversity and taxon-specific modifications of the RNA polymerase II C-terminal domain.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- On the computational ability of the RNA polymerase II carboxy terminal domain.Communicative & integrative biology · 2014Article
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe.Communicative & integrative biology · 2013Article
- Identification of differentially evolved genes: an alternative approach to detection of accelerated molecular evolution from genome-wide comparative data.Evolutionary bioinformatics online · 2013Article
- Decoding the informational properties of the RNA polymerase II Carboxy Terminal Domain.BMC research notes · 2012Article
- Functional characterization of a new member of the Cdk9 family in Aspergillus nidulans.Eukaryotic cell · 2010Article
- Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.Molecular biology and evolution · 2010Article
- RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter.Molecular and cellular biology · 2010Article
- Article
- Identification, structure, and functional requirement of the Mediator submodule Med7N/31.The EMBO journal · 2009Article
- Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.Nucleic acids research · 2008Article
- Nucleomorph genome of Hemiselmis andersenii reveals complete intron loss and compaction as a driver of protein structure and function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years a great deal of biochemical and genetic research has focused on the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II. This strongly conserved domain of tandemly repeated heptapeptides has been linked functionally to important steps in the initiation and processing of mRNA transcripts in both animals and fungi. Although they are absolutely required for viability in these organisms, C-terminal tandem repeats do not occur in RPB1 sequences from diverse eukaryotic taxa. Here we present phylogenetic analyses of RPB1 sequences showing that canonical CTD heptads are strongly conserved in only a subset of eukaryotic groups, all apparently descended from a single common ancestor. Moreover, eukaryotic groups in which the most complex patterns of ontogenetic development occur are descended from this CTD-containing ancestor. Consistent with the results of genetic and biochemical investigations of CTD function, these analyses suggest that the enhanced control over RNA polymerase II transcription conveyed by acquired CTD/protein interactions was an important step in the evolution of intricate patterns of gene expression that are a hallmark of large, developmentally complex eukaryotic organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.