ArticleMolecular and cellular biology2002
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 198 citations in OpenAlex.
- Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles.Aging · 2025Article
- Telomeric repeat-containing lncRNA TERRA targets non-telomeric DNA in trans via R-loops.Computational and structural biotechnology journal · 2025Article
- PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy.Frontiers in immunology · 2025Review
- Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases.Nature reviews. Molecular cell biology · 2024Review
- Maternal stress-induced changes in adolescent and adult offspring: Neurobehavioural improvement and telomere maintenance.Heliyon · 2023Article
- The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.Neuroscience and biobehavioral reviews · 2023Review
- Telomere DNA length regulation is influenced by seasonal temperature differences in short-lived but not in long-lived reef-building corals.Nature communications · 2023Article
- Reactive oxygen species-induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure.Journal of cellular and molecular medicine · 2022Article
- Functions of ADP-ribose transferases in the maintenance of telomere integrity.Cellular and molecular life sciences : CMLS · 2022Review
- Review
- Shelterin Complex at Telomeres: Implications in Ageing.Clinical interventions in aging · 2020Review
- A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure.Environmental research · 2020Article
- Telomere Maintenance in Pediatric Cancer.International journal of molecular sciences · 2019Review
- Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke.Frontiers in neurology · 2019Review
- The BUB3-BUB1 Complex Promotes Telomere DNA Replication.Molecular cell · 2018Article
- PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase.Genes & development · 2018Article
- Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Open biology · 2017Review
- The long and the short of TRF2 in neurogenesis.Cell cycle (Georgetown, Tex.) · 2016Review
- TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.Scientific reports · 2016Article
- Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the control of telomere length by the human telomeric proteins TRF1 and TRF2. To this end, we established telomerase-positive cell lines in which the targeting of these telomeric proteins to specific telomeres could be induced. We demonstrate that their targeting leads to telomere shortening. This indicates that these proteins act in cis to repress telomere elongation. Inhibition of telomerase activity by a modified oligonucleotide did not further increase the pace of telomere erosion caused by TRF1 targeting, suggesting that telomerase itself is the target of TRF1 regulation. In contrast, TRF2 targeting and telomerase inhibition have additive effects. The possibility that TRF2 can activate a telomeric degradation pathway was directly tested in human primary cells that do not express telomerase. In these cells, overexpression of full-length TRF2 leads to an increased rate of telomere shortening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.