ArticleMolecular and cellular biology2002
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.BMC genetics · 2020Article
- A variably occupied CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex.Molecular and cellular biology · 2015Article
- Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Human molecular genetics · 2014Article
- Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.Nucleic acids research · 2014Article
- Ectopically tethered CP190 induces large-scale chromatin decondensation.Scientific reports · 2014Article
- Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus.Nucleic acids research · 2013Article
- Genome-wide nucleosome positioning during embryonic stem cell development.Nature structural & molecular biology · 2012Article
- Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation.The Journal of biological chemistry · 2012Review
- Identification of imprinting regulators at the Meg3 differentially methylated region.Genomics · 2012Article
- A co-ordinated interaction between CTCF and ER in breast cancer cells.BMC genomics · 2011Article
- Article
- CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin.Chromosoma · 2010Review
- Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.PloS one · 2010Article
- H19 imprinting control region methylation requires an imprinted environment only in the male germ line.Molecular and cellular biology · 2010Article
- Does CTCF mediate between nuclear organization and gene expression?BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
- Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity.Current genomics · 2009Article
- Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains.Genome research · 2009Article
- Genomic imprinting mechanisms in mammals.Mutation research · 2008Review
- The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.Molecular cell · 2008Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The 5' region of the H19 gene harbors a methylation-sensitive chromatin insulator within an imprinting control region (ICR). Insertional mutagenesis in combination with episomal assays identified nucleosome positioning sequences (NPSs) that set the stage for the remarkably precise distribution of the four target sites for the chromatin insulator protein CTCF to nucleosome linker sequences in the H19 ICR. Changing positions of the NPSs resulted in loss of both CTCF target site occupancy and insulator function, suggesting that the NPSs optimize the fidelity of the insulator function. We propose that the NPSs ensure the fidelity of the repressed status of the maternal Igf2 allele during development by constitutively maintaining availability of the CTCF target sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.