ArticleMolecular and cellular biology2002
Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- RPA directly stimulates Mer3 helicase processivity to ensure normal crossover formation in meiosis.Nature communications · 2026Article
- An Orc1 initiator-specific motif (ISM)-related region limits ORC-ssDNA binding and promotes replication origin specificity in budding yeast.Frontiers in microbiology · 2026Article
- Meiosis-associated expression patterns during starvation-induced cell fusion in the protist Fisculla terrestris.BMC biology · 2025Article
- The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice.Biological research · 2024Article
- Biochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates.Nucleic acids research · 2023Article
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- SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over.Developmental cell · 2021Article
- Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over.Molecular cell · 2020Article
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- Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle.Genome research · 2016Article
- Sordaria, a model system to uncover links between meiotic pairing and recombination.Seminars in cell & developmental biology · 2016Review
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- Genome sequencing of four Aureobasidium pullulans varieties: biotechnological potential, stress tolerance, and description of new species.BMC genomics · 2014Article
- Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis.PLoS genetics · 2013Article
- Characterization of a set of novel meiotically-active promoters in Arabidopsis.BMC plant biology · 2012Article
- Nuclear inheritance and genetic exchange without meiosis in the binucleate parasite Giardia intestinalis.Journal of cell science · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Crossing over is regulated to occur at least once per each pair of homologous chromosomes during meiotic prophase to ensure proper segregation of chromosomes at the first meiotic division. In a mer3 deletion mutant of Saccharomyces cerevisiae, crossing over is decreased, and the distribution of the crossovers that occur is random. The predicted Mer3 protein contains seven motifs characteristic of the DExH box type of DNA/RNA helicases. The mer3G166D and the mer3K167A mutation, amino acid substitutions of conserved residues in a putative nucleotide-binding domain of the helicase motifs caused a defect in the transition of meiosis-specific double-strand breaks to later intermediates, decreased crossing over, and reduced crossover interference. The purified Mer3 protein was found to have DNA helicase activity. This helicase activity was reduced by the mer3GD mutation to <1% of the wild-type activity, even though binding of the mutant protein to single- and double-strand DNA was unaffected. The mer3KA mutation eliminated the ATPase activity of the wild-type protein. These results demonstrate that Mer3 is a DNA helicase that functions in meiotic crossing over.
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