ArticleThe Plant cell2002
A Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 178 citations in OpenAlex.
- Genomic Insights into Historical Adaptation of Three Key Fungal Plant Pathogens.Genome biology and evolution · 2025Article
- Host-induced gene silencing targeting the calcineurin ofFrontiers in plant science · 2025Article
- Beauveria bassiana transcriptomics reveal virulence-associated shifts during insect lipid assimilation.Applied microbiology and biotechnology · 2024Article
- Transcriptome Analysis Provides Insights into the Mechanism of the Transcription FactorInternational journal of molecular sciences · 2024Article
- Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17-2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Characterization and regulation of salt upregulated cyclophilin from a halotolerant strain of Penicillium oxalicum.Scientific reports · 2023Article
- Development and Validation of a HTS Platform for the Discovery of New Antifungal Agents against Four Relevant Fungal Phytopathogens.Journal of fungi (Basel, Switzerland) · 2023Article
- MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis inInternational journal of molecular sciences · 2023Article
- Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi.Frontiers in cell and developmental biology · 2023Review
- Proteomics Analysis Reveals the Molecular Mechanism of MoPer1 Regulating the Development and Pathogenicity ofFrontiers in cellular and infection microbiology · 2022Article
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- Cyclophilin BcCyp2 Regulates Infection-Related Development to Facilitate Virulence of the Gray Mold FungusInternational journal of molecular sciences · 2021Article
- Identification of effector candidate genes of Rhizoctonia solani AG-1 IA expressed during infection in Brachypodium distachyon.Scientific reports · 2020Article
- Genome-Wide Analysis of Cyclophilin Proteins in 21 Oomycetes.Pathogens (Basel, Switzerland) · 2019Article
- Genome-Wide Identification and Characterization of the Cyclophilin Gene Family in the Nematophagous FungusInternational journal of molecular sciences · 2019Article
- Functional Analysis of Peptidyl-prolylInternational journal of molecular sciences · 2019Article
- Genome-Wide Identification of Cyclophilin Gene Family in Cotton and Expression Analysis of the Fibre Development inInternational journal of molecular sciences · 2019Article
- Comparative genome analysis indicates high evolutionary potential of pathogenicity genes in Colletotrichum tanaceti.PloS one · 2019Article
- Host-induced silencing of essential genes in Puccinia triticina through transgenic expression of RNAi sequences reduces severity of leaf rust infection in wheat.Plant biotechnology journal · 2018Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclophilins are peptidyl prolyl cis-trans isomerases that are highly conserved throughout eukaryotes and that are best known for being the cellular target of the immunosuppressive drug cyclosporin A (CsA). The activity of CsA is caused by the drug forming a complex with cyclophilin A and inhibiting the calmodulin-dependent phosphoprotein phosphatase calcineurin. We have investigated the role of CYP1, a cyclophilin-encoding gene in the phytopathogenic fungus Magnaporthe grisea, which is the causal agent of rice blast disease. CYP1 putatively encodes a mitochondrial and cytosolic form of cyclophilin, and targeted gene replacement has shown that CYP1 acts as a virulence determinant in rice blast. Cyp1 mutants show reduced virulence and are impaired in associated functions, such as penetration peg formation and appressorium turgor generation. CYP1 cyclophilin also is the cellular target for CsA in Magnaporthe, and CsA was found to inhibit appressorium development and hyphal growth in a CYP1-dependent manner. These data implicate cyclophilins as virulence factors in phytopathogenic fungi and also provide evidence that calcineurin signaling is required for infection structure formation by Magnaporthe.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.