ArticleJournal of immunology (Baltimore, Md. : 1950)2002
Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs.The Journal of allergy and clinical immunology · 2021Article
- Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.Frontiers in immunology · 2018Review
- Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?Scientifica · 2014Review
- Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.Journal of autoimmunity · 2012Article
- Article
- The Ia.2 epitope defines a subset of lipid raft-resident MHC class II molecules crucial to effective antigen presentation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Molecular underpinning of B-cell anergy.Immunological reviews · 2010Review
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.The Journal of experimental medicine · 2009Article
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
- Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.Immunity · 2007Article
- The riddle of the dual expression of IgM and IgD.Immunology · 2006Review
- Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.The Journal of experimental medicine · 2006Article
- B cell antigen receptor signaling and internalization are mutually exclusive events.PLoS biology · 2006Article
- A genetic approach to inactivating chemokine receptors using a modified viral protein.Nature biotechnology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
B cell tolerance can be maintained by functional inactivation, or anergy, wherein B cell Ag receptors (BCR) remain capable of binding Ag, but are unable to transduce signals. Although the molecular mechanisms underlying this unresponsiveness are unknown, some models of B cell anergy are characterized by disruption of proximal BCR signaling events, and by destabilization of the BCR complex. Receptor destabilization is manifest by a reduced ability to coimmunoprecipitate membrane Ig with the Ig-alpha/Ig-beta signal-transducing complex. To begin to explore the possibility that anergy is the consequence of receptor destabilization, we analyzed a panel of B lymphoma transfectants expressing constant amounts of signal-competent Ag receptors and varied amounts of a receptor with identical specificity, but bearing mutations that render it incapable of interacting with Ig-alpha/Ig-beta. This analysis revealed that coaggregation of signal-incompetent receptors prevented Ag-induced Ig-alpha and Syk phosphorylation, mobilization of Ca(2+), and the up-regulation of CD69 mediated by competent receptors. In contrast, Ag-induced Cbl and Erk phosphorylation were unaffected. Data indicate that coaggregation of destabilized receptors (as few as approximately 15% of total) with signal-competent receptors significantly affects the ability of competent receptors to transduce signals. Thus, BCR destabilization may underlie the Ag unresponsiveness of anergic B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.