ArticleDevelopmental biology2002
Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.
Article in Developmental biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway.Medical oncology (Northwood, London, England) · 2024Article
- Cut homeodomain transcription factor is a novel regulator of growth and morphogenesis of cortex glia niche around neural cells.Genetics · 2024Article
- CUT homeobox genes: transcriptional regulation of neuronal specification and beyond.Frontiers in cellular neuroscience · 2023Review
- Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease.Kidney international · 2022Article
- Genomic studies controvert the existence of the CUX1 p75 isoform.Scientific reports · 2022Article
- CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation.Cancers · 2021Article
- CUX1, A Controversial Player in Tumor Development.Frontiers in oncology · 2020Review
- Cux1 regulation of the cyclin kinase inhibitor p27Gene: X · 2019Article
- Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.American journal of physiology. Renal physiology · 2017Article
- The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.Nucleic acids research · 2017Article
- Transforming growth factor-Biochemistry and biophysics reports · 2016Article
- The Groucho/Transducin-like enhancer of split protein family in animal development.IUBMB life · 2015Review
- The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.Oncotarget · 2015Article
- CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.Nature reviews. Cancer · 2014Review
- Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array.BMC genomics · 2013Article
- Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption.Journal of the American Society of Nephrology : JASN · 2013Article
- CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.Nucleic acids research · 2012Article
- MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.Nature communications · 2011Article
- Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.Developmental biology · 2011Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Cux-1 is a murine homeobox gene that is highly expressed in the developing kidney with expression restricted to the nephrogenic zone. Cux-1 is highly expressed in cyst epithelium of polycystic kidneys from C57BL/6J-cpk/cpk mice, but not in kidneys isolated from age-matched phenotypically normal littermates. To further elucidate the role of Cux-1 in renal development, we generated transgenic mice expressing Cux-1 under the control of the CMV immediate early gene promoter. Mice constitutively expressing Cux-1 developed multiorgan hyperplasia and organomegaly, but not an overall increase in body size. Transgenic kidneys were enlarged 50% by 6 weeks of age, with the increased growth primarily restricted to the cortex. Proliferating cells were found in proximal and distal tubule epithelium throughout the cortex, and the squamous epithelium that normally lines Bowman's capsule was replaced with proximal tubule epithelium. However, the total number of nephrons was not increased. In the developing kidneys of transgenic mice, Cux-1 was ectopically expressed in more highly differentiated tubules and glomeruli, and this was associated with reduced expression of the cyclin kinase inhibitor, p27. Transient transfection experiments revealed that Cux-1 is an inhibitor of p27 promoter activity. These results suggest that Cux-1 regulates cell proliferation during early nephrogenesis by inhibiting expression of p27.
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