ArticleProtein science : a publication of the Protein Society2002
Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information.
Article in Protein science : a publication of the Protein Society, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 117 citations in OpenAlex.
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- Conserved leucine-rich repeat proteins in the adhesive projectile slime of velvet worms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unusual structural and functional features of TpLRR/BspA-like LRR proteins.Journal of structural biology · 2023Review
- Identifying Natural Bioactive Peptides from the Common Octopus (International journal of molecular sciences · 2023Article
- LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy.Frontiers in immunology · 2023Article
- LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.International journal of molecular sciences · 2022Article
- Haplotype-resolved powdery mildew resistance loci reveal the impact of heterozygous structural variation on NLR genes in Muscadinia rotundifolia.G3 (Bethesda, Md.) · 2022Article
- In-depth comparative analysis of Tritrichomonas foetus transcriptomics reveals novel genes linked with adaptation to feline host.Scientific reports · 2022Article
- NLRexpress-A bundle of machine learning motif predictors-Reveals motif stability underlying plant Nod-like receptors diversity.Frontiers in plant science · 2022Article
- Designed leucine-rich repeat proteins bind two muramyl dipeptide ligands.Protein science : a publication of the Protein Society · 2021Article
- Toll-Like Receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective.Advances in experimental medicine and biology · 2021Article
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- Pediatric Dilated Cardiomyopathy-AssociatedJournal of the American Heart Association · 2018Article
- Genetic mapping and development of co-segregating markers of RpsQ, which provides resistance to Phytophthora sojae in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- LRRC3B is downregulated in non-small-cell lung cancer and inhibits cancer cell proliferation and invasion.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.PloS one · 2013Article
- Identification of positive selection in disease response genes within members of the Poaceae.Plant signaling & behavior · 2012Article
- A computational model of the LGI1 protein suggests a common binding site for ADAM proteins.PloS one · 2011Article
- Leureptin: a soluble, extracellular leucine-rich repeat protein from Manduca sexta that binds lipopolysaccharide.Insect biochemistry and molecular biology · 2010Article
- Comprehensive modeling and functional analysis of Toll-like receptor ligand-recognition domains.Protein science : a publication of the Protein Society · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The three-dimensional structures of leucine-rich repeat (LRR)-containing proteins from five different families were previously predicted based on the crystal structure of the ribonuclease inhibitor, using an approach that combined homology-based modeling, structure-based sequence alignment of LRRs, and several rational assumptions. The structural models have been produced based on very limited sequence similarity, which, in general, cannot yield trustworthy predictions. Recently, the protein structures from three of these five families have been determined. In this report we estimate the quality of the modeling approach by comparing the models with the experimentally determined structures. The comparison suggests that the general architecture, curvature, "interior/exterior" orientations of side chains, and backbone conformation of the LRR structures can be predicted correctly. On the other hand, the analysis revealed that, in some cases, it is difficult to predict correctly the twist of the overall super-helical structure. Taking into consideration the conclusions from these comparisons, we identified a new family of bacterial LRR proteins and present its structural model. The reliability of the LRR protein modeling suggests that it would be informative to apply similar modeling approaches to other classes of solenoid proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.