ArticleOncogene2002
Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 212 citations in OpenAlex.
- Claudin 18.2 as a novel therapeutic target.Nature reviews. Clinical oncology · 2024Review
- Clinical Significance of Claudin Expression in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2022Article
- Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype.Cancers · 2021Article
- Integrated genomic and methylation profile analysis to identify candidate tumor marker genes in patients with colorectal cancer.Oncology letters · 2019Article
- Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility.The Journal of biological chemistry · 2019Article
- Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers.Scientific reports · 2018Article
- Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays.Oncotarget · 2018Article
- Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups.British journal of cancer · 2017Article
- Genetic expression signatures of oral submucous fibrosis and oral cancer-A preliminary microarray report.Journal of dental sciences · 2016Article
- Clinical significance of serum claudin-1 and claudin-7 levels in patients with colorectal cancer.Molecular and clinical oncology · 2015Article
- Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis.Oncotarget · 2015Article
- A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment.Molecular cancer · 2015Article
- CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma.Oncotarget · 2014Article
- Claudin-4 expression in gastric cancer cells enhances the invasion and is associated with the increased level of matrix metalloproteinase-2 and -9 expression.Oncology letters · 2014Article
- Human papillomaviruses-related cancers. Presence and prevention strategies in the Middle east and north African regions.Human vaccines & immunotherapeutics · 2014Review
- The prognostic role of claudins in head and neck squamous cell carcinomas.Pathology oncology research : POR · 2014Article
- High-Risk HPVs and Human Carcinomas in the Syrian Population.Frontiers in oncology · 2014Review
- Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue.Virology · 2013Article
- The claudin family of proteins in human malignancy: a clinical perspective.Cancer management and research · 2013Review
- Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma.BMC medical genomics · 2013Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to identify genes involved in head and neck carcinogenesis, we compared the gene expression profile in matched primary normal epithelial cells and primary head and neck cancer cells from the same patients. A cDNA microarray analysis consisting of 12 530 human genes revealed significant changes in the expression of 213 genes, with 91 genes being up-regulated and 122 being down-regulated. This comprehensive list of genes includes those associated with signal transduction (growth factors), cell structure, cell cycle, transcription, apoptosis, and cell-cell adhesion. Further analysis of nine genes involved in cell-cell interaction, using Western blot and/or reverse transcription (RT)-PCR of four paired cell lines supported the reliability of our microarray analysis. More specifically, our study provides the first evidence that claudin-7 and connexin 31.1 are down-regulated in head and neck squamous cell carcinomas (HNSCC) compared to normal cells. These findings provide a large body of information regarding gene expression profiles associated with head and neck carcinogenesis, and also represent a source of potential targets for HNSCC prevention and/or therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.