Evidence map›Paper›PMID 11965502›Full record

ReviewEuropean journal of clinical nutrition2002

The anemia of vitamin A deficiency: epidemiology and pathogenesis.

R D Semba, M W Bloem

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of clinical nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 356 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Determinants of Anemia and Hemoglobin Concentration in Haitian School-Aged Children.The American journal of tropical medicine and hygiene · 2015
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Review
  15. Article
  16. Review
  17. Article
  18. Anaemia: A Scientific Overview on Types and Recent Advancements in the Detection of Anaemia.Cardiovascular & hematological agents in medicinal chemistry · 2026
    Review
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R D SembaDepartment of Ophthalmology Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. rdsemba@jhmi.edu
M W Bloem
Johns Hopkins Medicine · US

Funding

ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDSR01AI041956 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 1998 to 2005
$3.0M
VITAMIN A SUPPLEMENTATION FOR HIV-INFECTED CHILDRENR01HD030042 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 1995 to 2002
$1.4M
MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIVR01HD032247 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 1995 to 2001
$1.1M
VITAMIN A SUPPLEMENTATION FOR HIV-INFECTED CHILDRENR55HD030042 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 1993 to 1993
–
NIAID NIH HHS AI41956NICHD NIH HHS HD30042NICHD NIH HHS HD32247
6 · The paper itself

Abstract

objectiveTo gain insight into vitamin A deficiency as a cause of anemia.

methodsComprehensive review of the scientific literature.

resultsAlthough vitamin A deficiency is recognized to cause anemia, 'vitamin A deficiency anemia' lacks complete characterization as a distinct clinical entity. Vitamin A appears to be involved in the pathogenesis of anemia through diverse biological mechanisms, such as the enhancement of growth and differentiation of erythrocyte progenitor cells, potentiation of immunity to infection and reduction of the anemia of infection, and mobilization of iron stores from tissues. Epidemiological surveys show that the prevalence of anemia is high in populations affected by vitamin A deficiency in developing countries. Improvement of vitamin A status has generally been shown to reduce anemia, but the actual public health impact on anemia is unclear.

conclusionsFurther work is needed to elucidate the biological mechanisms by which vitamin A causes anemia. The inclusion of anemia as an outcome measure in future micronutrient intervention studies should help provide further insight into the anemia of vitamin A deficiency.

Indexed as

AdolescentAdultAnemiaChildChild, PreschoolFemaleHumansInfantMalePregnancyVitamin A Deficiency

Identifiers

PMID11965502
OpenAlexW2006588236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.