ArticleEMBO reports2002
The polarized epithelia-specific mu 1B-adaptin complements mu 1A-deficiency in fibroblasts.
Article in EMBO reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Deficiency of AP1 ComplexInternational journal of molecular sciences · 2023Article
- Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species.International journal of molecular sciences · 2021Review
- Review
- Adaptor proteins involved in polarized sorting.The Journal of cell biology · 2014Review
- Response: the "tail" of the twin adaptors.Developmental cell · 2013Article
- The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells.Developmental cell · 2013Article
- Adaptor protein 1 complexes regulate intracellular trafficking of the kidney anion exchanger 1 in epithelial cells.American journal of physiology. Cell physiology · 2012Article
- The clathrin adaptor AP-1A mediates basolateral polarity.Developmental cell · 2012Article
- Arf6 regulates AP-1B-dependent sorting in polarized epithelial cells.The Journal of cell biology · 2011Article
- ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.The Journal of cell biology · 2011Article
- Clathrin adaptor AP-2 is essential for early embryonal development.Molecular and cellular biology · 2005Article
- The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells.The Journal of cell biology · 2003Article
- The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains.The Journal of cell biology · 2003Article
- Role of the epithelial cell-specific clathrin adaptor complex AP-1B in cell polarity.Cellular logisticsReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heterotetrameric AP-1A adaptor complex of clathrin-coated vesicles is ubiquitously expressed. The mu 1-adaptin subunit of the complex exists as the ubiquitous mu 1A and the polarized epithelia-specific mu 1B, which are 80% identical. In polarized epithelia, mu 1B is incorporated into the AP-1B complex, which is required for basolateral plasma membrane sorting of the low-density lipoprotein receptor. Binding of AP-1B to subdomains of the trans-Golgi network (TGN) appears to be part of the mechanism by which protein sorting is mediated. We expressed mu 1B in mu 1A-deficient fibroblasts to test for mu 1B function in non-polarized cells. AP-1B complexes were formed and bound to the TGN and to endosomes. Moreover, AP-1B restored the AP-1A-dependent sorting of mannose 6-phosphate receptors between endosomes and the TGN. This demonstrates that mu 1A and mu 1B do have overlapping sorting functions and indicates that AP-1A and AP-1B mediate protein sorting along parallel pathways between the TGN and endosomes in polarized epithelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.