ArticleBiophysical journal2002
Shear flow-induced detachment kinetics of Dictyostelium discoideum cells from solid substrate.
Article in Biophysical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Reduced cell-substrate adhesion formation promotes cell migration inMolecular biology of the cell · 2025Article
- Reduced cell-substrate adhesion formation promotes cell migration inbioRxiv : the preprint server for biology · 2025Article
- Theoretical and Experimental Studies of the Dynamic Damage of Endothelial Cellular Networks Under Ultrasound Cavitation.Cellular and molecular bioengineering · 2025Article
- A Microfluidic Design for Quantitative Measurements of Shear Stress-Dependent Adhesion and Motion ofBiomimetics (Basel, Switzerland) · 2024Article
- Modelling how curved active proteins and shear flow pattern cellular shape and motility.Frontiers in cell and developmental biology · 2023Article
- Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces.Molecules (Basel, Switzerland) · 2022Article
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Optimal pulse length of insonification for Piezo1 activation and intracellular calcium response.Scientific reports · 2021Article
- Cellular velocity, electrical persistence and sensing in developed and vegetative cells during electrotaxis.PloS one · 2020Article
- Correlation ofRSC advances · 2018Article
- Hydrodynamics in Cell Studies.Chemical reviews · 2018Review
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- Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Interplay between motility and cell-substratum adhesion in amoeboid cells.Biomicrofluidics · 2015Article
- Rectified directional sensing in long-range cell migration.Nature communications · 2014Article
- A simple force-motion relation for migrating cells revealed by multipole analysis of traction stress.Biophysical journal · 2014Article
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- The influence of inhomogeneous adhesion on the detachment dynamics of adhering cells.European biophysics journal : EBJ · 2013Article
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Authors and funding
5 authors.
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Abstract
Using Dictyostelium discoideum as a model organism of specific and nonspecific adhesion, we studied the kinetics of shear flow-induced cell detachment. For a given cell, detachment occurs for values of the applied hydrodynamic stress above a threshold. Cells are removed from the substrate with an apparent first-order rate constant that strongly depends on the applied stress. The threshold stress depends on cell size and physicochemical properties of the substrate, but is not affected by depolymerization of the actin and tubulin cytoskeleton. In contrast, the kinetics of cell detachment is almost independent of cell size, but is strongly affected by a modification of the substrate and the presence of an intact actin cytoskeleton. These results are interpreted in the framework of a peeling model. The threshold stress and the cell-detachment rate measure the local equilibrium energy and the dissociation rate constant of the adhesion bridges, respectively.
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