ArticleThe Biochemical journal2002
Gal3p and Gal1p interact with the transcriptional repressor Gal80p to form a complex of 1:1 stoichiometry.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Sustainable β-carotene production by engineered S. cerevisiae using sucrose and agricultural by-products.Bioresources and bioprocessing · 2025Article
- Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2024Article
- Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components.mSphere · 2023Article
- Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation.PLoS computational biology · 2021Article
- Computational study on ratio-sensing in yeast galactose utilization pathway.PLoS computational biology · 2020Article
- Multi-component gene network design as a survival strategy in diverse environments.BMC systems biology · 2018Article
- Genetic and Epigenetic Strategies Potentiate Gal4 Activation to Enhance Fitness in Recently Diverged Yeast Species.Current biology : CB · 2017Article
- Noise reduction facilitated by dosage compensation in gene networks.Nature communications · 2016Article
- Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network.eLife · 2016Article
- A cell size- and cell cycle-aware stochastic model for predicting time-dynamic gene network activity in individual cells.BMC systems biology · 2015Article
- Network-dosage compensation topologies as recurrent network motifs in natural gene networks.BMC systems biology · 2014Article
- Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.Molecular and cellular biology · 2013Article
- A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast.Molecular biology of the cell · 2013Article
- Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular simulation and docking studies of Gal1p and Gal3p proteins in the presence and absence of ligands ATP and galactose: implication for transcriptional activation of GAL genes.Journal of computer-aided molecular design · 2012Article
- Rapid GAL gene switch of Saccharomyces cerevisiae depends on nuclear Gal3, not nucleocytoplasmic trafficking of Gal3 and Gal80.Genetics · 2011Article
- Comparative modeling and genomics for galactokinase (Gal1p) enzyme.Bioinformation · 2011Article
- A general mechanism for network-dosage compensation in gene circuits.Science (New York, N.Y.) · 2010Article
- Galactose toxicity in animals.IUBMB life · 2009Review
- Inferring Transcriptional Interactions by the Optimal Integration of ChIP-chip and Knock-out Data.Bioinformatics and biology insights · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes encoding the enzymes required for galactose metabolism in Saccharomyces cerevisiae are controlled at the level of transcription by a genetic switch consisting of three proteins: a transcriptional activator, Gal4p; a transcriptional repressor, Gal80p; and a ligand sensor, Gal3p. The switch is turned on in the presence of two small molecule ligands, galactose and ATP. Gal3p shows a high degree of sequence identity with Gal1p, the yeast galactokinase. We have mapped the interaction between Gal80p and Gal3p, which only occurs in the presence of both ligands, using protease protection experiments and have shown that this involves amino acid residue 331 of Gal80p. Gel-filtration experiments indicate that Gal3p, or the galactokinase Gal1p, interact directly with Gal80p to form a complex with 1:1 stoichiometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.