ArticleBMC neuroscience2002
Advanced analysis of a cryptochrome mutation's effects on the robustness and phase of molecular cycles in isolated peripheral tissues of Drosophila.
Article in BMC neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 94 citations in OpenAlex.
- Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity inbioRxiv : the preprint server for biology · 2025Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity.Genes & development · 2021Article
- Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock inFrontiers in physiology · 2021Review
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- Single-cell resolution long-term luciferase imaging in cultivatedmicroPublication biology · 2020Article
- Review
- One Actor, Multiple Roles: The Performances of Cryptochrome inFrontiers in physiology · 2020Review
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- Article
- Temperature synchronization of theCommunications biology · 2019Article
- Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration.Brain communications · 2019Article
- Nighttime activities and peripheral clock oscillations depend on Wolbachia endosymbionts in flies.Scientific reports · 2018Article
- Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in aThe Journal of biological chemistry · 2018Article
- Neural Network Interactions Modulate CRY-Dependent Photoresponses inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Non-canonical Phototransduction Mediates Synchronization of the Drosophila melanogaster Circadian Clock and Retinal Light Responses.Current biology : CB · 2018Article
- Reflections on contributing to "big discoveries" about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young.Neurobiology of sleep and circadian rhythms · 2018Review
- CLOCK stabilizes CYCLE to initiate clock function inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes.Neurobiology of disease · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreviously, we reported effects of the cry(b) mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We relied on luciferase activity driven by the respective regulatory genomic elements to provide real-time reporting of cycling gene expression. Subsequently, we developed a tool kit for the analysis of behavioral and molecular cycles. Here, we use these tools to analyze our earlier results as well as additional data obtained using the same experimental designs.
resultsIsolated antennal pairs, heads, bodies, wings and forelegs were evaluated under light-dark cycles. In these conditions, the cry(b) mutation significantly decreases the number of rhythmic specimens in each case except the wing. Moreover, among those specimens with detectable rhythmicity, mutant rhythms are significantly weaker than cry+ controls. In addition, cry(b) alters the phase of period gene expression in these tissues. Furthermore, peak phase of luciferase-reported period and timeless expression within cry+ samples is indistinguishable in some tissues, yet significantly different in others. We also analyze rhythms produced by antennal pairs in constant conditions.
conclusionsThese analyses further show that circadian clock mechanisms in Drosophila may vary in a tissue-specific manner, including how the cry gene regulates circadian gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.