ArticleLeukemia2002
ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukemia.
Article in Leukemia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Genetic, Cytogenetic and Hematological Features in Newly Diagnosed Acute Lymphoid Leukemia Patients under Eighteen Years Age Referred to Ali Asghar Hospital of Tehran, Iran, from 2013 to 2023.Cardiovascular & hematological disorders drug targets · 2025Article
- A Retrospective Cytogenetic Abnormality in Pediatric Acute Lymphoblastic Leukemia: Report of 11 Years.Advanced biomedical research · 2022Article
- The power of microRNAs as diagnostic and prognostic biomarkers in liquid biopsies.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Gene Fusion in Malignant Glioma: An Emerging Target for Next-Generation Personalized Treatment.Translational oncology · 2018Review
- Recent advances in the biology and treatment of B-cell acute lymphoblastic leukemia.Blood and lymphatic cancer : targets and therapy · 2018Review
- Secretory carcinoma - impact of translocation and gene fusions on salivary gland tumor.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- Pathological features of mammary analogue secretory carcinoma of the salivary gland.International journal of clinical and experimental pathology · 2017Article
- New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.Haematologica · 2016Review
- Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.Oncotarget · 2016Article
- Cytogenetic findings of patients with acute lymphoblastic leukemia in fars province.Iranian journal of medical sciences · 2013Article
- Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.Haematologica · 2010Article
- Cytogenetics and molecular genetics of acute lymphoblastic leukemia.Hematology/oncology clinics of North America · 2009Review
- Guidance for fluorescence in situ hybridization testing in hematologic disorders.The Journal of molecular diagnostics : JMD · 2007Article
- Article
- Review
- High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias.Leukemia · 2004Article
- Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome.Leukemia · 2003Article
- Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases.Leukemia · 2003Review
- Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dual-color interphase fluorescence in situ hybridization (FISH) with ETV6 and AML1 probes was used for the first time on a series of 159 adult patients with acute lymphoblastic leukemia (ALL), for detection of the t(12;21)(p13;q22) translocation. Seven patients (4.4%) were found, with 50-100% of positive cells, of whom one of two tested, proved negative for the fusion product by RT-PCR. Two of them, aged 43 and 50 years, are the oldest patients so far confirmed to have the translocation. Three who relapsed at 10, 11 and 24 months, suggest that adults may not enjoy the good short-term prognosis reported for t(12;21)-positive children. Thirty-one-negative cases had signal numbers differing from the two expected for each gene. In 15 cases these results were consistent with the karyotype. In nine cases with uninformative cytogenetics, the numbers were consistent with those for centromeres and indicated a hidden aneuploidy. Loss of ETV6 genes in two cases and AML1 amplification in three others were not suspected from the cytogenetics. In conclusion, FISH proved to be reliable in defining ETV6/AML1 positivity in this group of patients as well as providing valuable insights into negative cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.