ArticleGenes and immunity2002
Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 165 citations in OpenAlex.
- Trial
- Killer cell immunoglobulin-like receptor alleles influence susceptibility to occult hepatitis B infection in West African population.Journal of public health in Africa · 2023Article
- High-Resolution Characterization ofFrontiers in immunology · 2021Article
- Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon.Journal of immunology research · 2021Article
- Haplotype-Based Analysis ofFrontiers in immunology · 2020Article
- KIR gene presence/absence polymorphisms and global diversity in the Kirgiz ethnic minority and populations distributed worldwide.Molecular biology reports · 2019Article
- Article
- Genetic polymorphism and evolutionary differentiation of Eastern Chinese Han: a comprehensive and comparative analysis on KIRs.Scientific reports · 2017Article
- Two new cases of KIR3DP1, KIR2DL4-negative genotypes, one of which is also lacking KIR3DL2.Archivum immunologiae et therapiae experimentalis · 2014Article
- Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.PLoS neglected tropical diseases · 2014Article
- Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses.PloS one · 2014Article
- Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.Genome medicine · 2014Article
- Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population.Immunogenetics · 2013Article
- Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.BMC genomics · 2013Article
- Genetics of graft-versus-host disease: the major histocompatibility complex.Blood reviews · 2013Review
- A database for curating the associations between killer cell immunoglobulin-like receptors and diseases in worldwide populations.Database : the journal of biological databases and curation · 2013Article
- Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors.Genome research · 2012Article
- Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population.Molecular biology reports · 2012Article
- Diversity of killer cell immunoglobulin-like receptor genes in Southern Turkey.Molecular biology reports · 2012Article
- Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.PloS one · 2012Article
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. Pc < 1 x 10(-6)) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (Pc < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.