ArticleProceedings of the National Academy of Sciences of the United States of America2002
Resting and circadian release of nitric oxide is controlled by leptin in male rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
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- Effects of mastication on antibody production under fasting conditions in mice.International journal of medical sciences · 2023Article
- Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks.Biology · 2021Review
- Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2020Review
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- The Local Regulation of Vascular Function: From an Inside-Outside to an Outside-Inside Model.Frontiers in physiology · 2019Review
- The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.Frontiers in physiology · 2019Review
- IncreasedFrontiers in physiology · 2018Article
- The role of perivascular adipose tissue in obesity-induced vascular dysfunction.British journal of pharmacology · 2017Review
- Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats.Balkan medical journal · 2016Article
- Chronic variable stress improves glucose tolerance in rats with sucrose-induced prediabetes.Psychoneuroendocrinology · 2014Article
- Biological aging alters circadian mechanisms in murine adipose tissue depots.Age (Dordrecht, Netherlands) · 2013Article
- Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study.Experimental and therapeutic medicine · 2012Article
- High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2011Article
- Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Review
- Leptin promotes melanoma tumor growth in mice related to increasing circulating endothelial progenitor cells numbers and plasma NO production.Journal of experimental & clinical cancer research : CR · 2011Article
- Neuroprotection by radical avoidance: search for suitable agents.Molecules (Basel, Switzerland) · 2009Review
- Pressed for time: the circadian clock and hypertension.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Because leptin stimulates nitric oxide (NO) release from the hypothalamus and anterior pituitary gland, we hypothesized that it also might release NO from adipocytes, the principal source of leptin. Consequently, plasma concentrations of leptin and NO, estimated from its metabolites NO(3) and NO(2) (NO(3)-NO(2)), were measured in adult male rats. There was a linear increase of both leptin and NO(3)-NO(2) with body weight that was associated with a parallel rise in fat mass. These findings indicate that release of leptin and NO is directly related to adipocyte mass. Furthermore, there was a parallelism in circadian rhythm of both substances, with peaks at 0130 h and nadirs at 0730 h. Measurement of both leptin and NO(3)-NO(2) in plasma from individual rats revealed that NO(3)-NO(2) increased linearly with leptin. Incubation of epididymal fat pads with leptin or its i.v. injection in conscious rats increased NO(3)-NO(2) release. The release of NO(3)-NO(2) in vivo and in vitro exceeded that of leptin by many fold, indicating that leptin activates NO synthase. Leptin increased tumor necrosis factor (TNF)-alpha release at a 100-fold lower dose than required for NO release in vitro and in vivo, suggesting that it also may participate in leptin-induced NO release. However, because many molecules of leptin were required to release a molecule of TNF-alpha in vivo and in vitro, we believe that leptin-induced TNF-alpha release is an associated phenomenon not involved in NO production. The results support the hypothesis that adipocytes play a major role in NO release by activating NO synthase in the adipocytes and the adjacent capillary endothelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.