ArticleProceedings of the National Academy of Sciences of the United States of America2002
Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
- Research progress of PBX1 in developmental and regenerative medicine.International journal of medical sciences · 2023Review
- Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis.Nature communications · 2021Article
- FAN-C: a feature-rich framework for the analysis and visualisation of chromosome conformation capture data.Genome biology · 2020Article
- Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.Molecular biology of the cell · 2015Article
- Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.Developmental cell · 2011Article
- Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues.PLoS biology · 2010Article
- Zic3 is required for maintenance of pluripotency in embryonic stem cells.Molecular biology of the cell · 2007Article
- TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.Developmental biology · 2007Article
- Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.Molecular and cellular biology · 2006Article
- Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.Genes & development · 2002Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pbx1 is a homeodomain protein that functions in complexes with other homeodomain-containing proteins to regulate gene expression during embryogenesis and oncogenesis. Pbx proteins bind DNA cooperatively as heterodimers or higher order complexes with Meis family members and Hox proteins and are believed to specify cell identity during development. Here, we present evidence that Pbx1, in partnership with Meis1b, can regulate posterior neural markers and neural crest marker genes during Xenopus development. A Xenopus homolog of the Pbx1b homeodomain protein was isolated and shown to be expressed throughout embryogenesis. Xpbx1b expression overlaps with Xmeis1 in several areas, including the lateral neural folds, caudal branchial arch, hindbrain, and optic cup. When ectopically expressed, Xpbx1b can synergize with Xmeis1b to promote posterior neural and neural crest gene expression in ectodermal explants. Further, a physical interaction between these two homeodomain proteins is necessary for induction of these genes in embryonic tissue. In addition, coexpression of Xmeis1b and Xpbx1b leads to a prominent shift in the localization of Xmeis1b from the cytoplasm to the nucleus, suggesting that nuclear transport or retention of Xmeis1b may depend upon Xpbx1b. Finally, expression of a mutant construct in which Xpbx1b protein is fused to the repressor domain from Drosophila Engrailed inhibits posterior neural and neural crest gene expression. These data indicate that Xpbx1b and its partner, Xmeis1b, function in a transcriptional activation complex during hindbrain and neural crest development.
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