ArticleBritish journal of pharmacology2002
Complex regional haemodynamic effects of anandamide in conscious rats.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Acute and long-term effects of cannabinoids on hypertension and kidney injury.Scientific reports · 2022Article
- Targeting of G-protein coupled receptors in sepsis.Pharmacology & therapeutics · 2020Review
- Endovanilloids are potential activators of the trigeminovascular nocisensor complex.The journal of headache and pain · 2016Article
- Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach.Pharmacology research & perspectives · 2015Article
- The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure.The Journal of pharmacology and experimental therapeutics · 2014Article
- Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.PloS one · 2013Article
- Mechanisms of endothelial dysfunction in obesity-associated hypertension.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?British journal of pharmacology · 2012Review
- Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor responses in conscious rats.Brain research · 2011Article
- A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats.British journal of pharmacology · 2010Article
- Factors influencing the regional haemodynamic responses to methanandamide and anandamide in conscious rats.British journal of pharmacology · 2009Article
- The emerging role of the endocannabinoid system in cardiovascular disease.Seminars in immunopathology · 2009Review
- Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.British journal of pharmacology · 2009Article
- Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations.Hypertension (Dallas, Tex. : 1979) · 2008Review
- The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathyic rats: evidence at the cannabinoid CB1 receptor.The Journal of physiology · 2008Article
- Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats.British journal of pharmacology · 2007Article
- Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat.British journal of pharmacology · 2007Article
- Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.British journal of pharmacology · 2007Article
- Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.British journal of pharmacology · 2007Article
- Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.British journal of pharmacology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Experiments were carried out in conscious, chronically instrumented, male, Sprague-Dawley rats to delineate the regional haemodynamic effects of the putative endogenous cannabinoid, anandamide, (0.075 - 3 mg kg(-1)), and to dissect some of the mechanisms involved. 2. At all doses of anandamide, there was a significant, short-lived increase in mean arterial blood pressure associated with vasoconstriction in renal, mesenteric and hindquarters vascular beds. 3. The higher doses (2.5 and 3 mg kg(-1)), caused an initial, marked bradycardia accompanied, in some animals, by a fall in arterial blood pressure which preceded the hypertension. In addition, after the higher doses of anandamide, the hindquarters vasoconstriction was followed by vasodilatation. 4. Although some of the effects described above resembled those of 5-HT (25 microg kg(-1)), the bradycardia and hypotensive actions of the latter were abolished by the 5HT(3)-receptor antagonist, azasetron, whereas those of anandamide were generally unaffected. 5. None of the cardiovascular actions of anandamide were influenced by the CB(1)-receptor antagonist, AM 251, but its bradycardic effect was sensitive to atropine, and its hindquarters vasodilator action was suppressed by the beta(2)-adrenoceptor antagonist, ICI 118551. 6. The results differ, in several aspects, from those previously reported in anaesthetized animals, and underscore the important impact anaesthesia can have on responses to anandamide.
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