ArticleNeurochemical research2002
Subunit composition and function of GABAA receptors of rat spermatozoa.
Article in Neurochemical research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.The Journal of reproduction and development · 2026Article
- High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes.Clinical and experimental reproductive medicine · 2021Article
- Recovery effect of pre-germinated brown rice on the changes of sperm quality, testicular structure and androgen receptor expression in a rat model of drug addiction.International journal of medical sciences · 2018Article
- γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine.The Journal of reproduction and development · 2017Article
- Characteristic expressions of GABA receptors and GABA producing/transporting molecules in rat kidney.PloS one · 2014Article
- Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by γ-aminobutyric acid.The Journal of reproduction and development · 2014Article
- Dynamic regulation of glutamate decarboxylase 67 gene expression by alternative promoters and splicing during rat testis maturation.Molecular biology reports · 2010Article
- The protective effects of alpha-ketoacids against oxidative stress on rat spermatozoa in vitro.Asian journal of andrology · 2010Article
- Gamma-aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAReproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABA triggers mammalian sperm acrosome reaction (AR). Here, evidence is presented, showing that rat spermatozoa contain GABAA receptors, composed of alpha5, beta1 and beta3 subunits. The effects of GABAA receptor agonist and antagonist on the induction of AR in rat spermatozoa were assessed using the chlortetracycline assay. Muscimol, a GABAA receptor agonist, triggered AR; whereas bicuculline, a GABAA receptor antagonist and picrotoxin, a GABAA receptor/Cl- channel blocker, inhibited the ability of GABA or progesterone to induce AR. In conclusion, GABAA receptors appear to mediate the action of progesterone in inducing AR in rat spermatozoa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.