ArticleBrain pathology (Zurich, Switzerland)2002
Allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomas.
Article in Brain pathology (Zurich, Switzerland), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas.Life (Basel, Switzerland) · 2023Review
- Molecular characteristics of meningiomas.Journal of pathology and translational medicine · 2020Review
- Protein Kinase A Distribution in Meningioma.Cancers · 2019Article
- Deletions in the 17q chromosomal region and their influence on the clonal cytogenetic evolution of recurrent meningiomas.Molecular cytogenetics · 2019Article
- Emerging Medical Treatments for Meningioma in the Molecular Era.Biomedicines · 2018Review
- Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.Oncotarget · 2016Article
- Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications.Frontiers in surgery · 2016Review
- Review
- Article
- Update on meningiomas.The oncologist · 2011Review
- Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome.Journal of neuropathology and experimental neurology · 2009Article
- Methylation-specific multiplex ligation-dependent probe amplification in meningiomas.Journal of neuro-oncology · 2008Article
- Molecular biology of unreresectable meningiomas: implications for new treatments and review of the literature.Skull base : official journal of North American Skull Base Society ... [et al.] · 2008Article
- Comprehensive genetic and epigenetic analysis of sporadic meningioma for macro-mutations on 22q and micro-mutations within the NF2 locus.BMC genomics · 2007Article
- Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.Journal of neuro-oncology · 2007Article
- Molecular pathogenesis of meningiomas.Journal of neuro-oncology · 2004Review
- Brain tumours: classification and genes.Journal of neurology, neurosurgery, and psychiatry · 2004Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using comparative genomic hybridization (CGH) we have previously identified amplification at 17q21-qter as a common aberration in anaplastic meningiomas but not in atypical or benign meningiomas (19). To define the amplified genomic region, we analyzed 44 meningeal tumors, including 7 benign meningiomas of World Health Organization (WHO) grade 1,19 atypical meningiomas (WHO grade II) and 18 anaplastic meningiomas (WHO grade III) at 46 chromosome 17 loci (including 42 17q loci). In line with the CGH data we found evidence of increased numbers of alleles on 17q. The incidence rose with malignancy grade, culminating at 61% (11 of 18 cases) in the anaplastic meningioma group. The majority of cases showing increased allele numbers had, on average, low-level allelic gains (relative increase in allele dosage of 2- to 5-fold). Amplification of alleles (defined here as an average relative increase in allele dosage of more than 5 times) was detected in 2 anaplastic meningiomas. The amplification patterns in these tumors defined a number of common regions of amplification/increased allele copy number, the best defined include one between D17S790 and D17S1607 and one between D17S1160 and PS6K. Real-time PCR analysis of the PS6K candidate gene revealed no high-level amplification despite this affecting adjacent loci. Our findings are fundamental for the identification of the gene(s) in 17q22-q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types.
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