Trial reportThe Journal of physiology2002
The intent to exercise influences the cerebral O(2)/carbohydrate uptake ratio in humans.
Trial report in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise.The Journal of physiology · 2011Trial
- The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans.The Journal of physiology · 2008Trial
- Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance.The Journal of physiology · 2008Trial
- Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans.The Journal of physiology · 2007Trial
- Brain and central haemodynamics and oxygenation during maximal exercise in humans.The Journal of physiology · 2004Trial
- Physiological predictors of exercise-induced increases in circulating BDNF isoforms and net cerebral lactate exchange in healthy adults.Frontiers in physiology · 2026Article
- Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia.The Journal of physiology · 2025Article
- Alzheimer's Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria-Associated Metabolic Pathways Through Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2).Antioxidants (Basel, Switzerland) · 2025Review
- Current knowledge about pyruvate supplementation: A brief review.Sports medicine and health science · 2024Review
- A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.Neuroscience and biobehavioral reviews · 2023Review
- Attentive Processes and Blood Lactate in the Sambo.International journal of environmental research and public health · 2022Article
- Review
- Peripheral Modulators of the Central Fatigue Development and Their Relationship with Athletic Performance in Jumper Horses.Animals : an open access journal from MDPI · 2021Article
- Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance.PloS one · 2019Article
- Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate.Frontiers in neuroscience · 2019Article
- A trade-off between cognitive and physical performance, with relative preservation of brain function.Scientific reports · 2017Article
- The impact of age on cerebral perfusion, oxygenation and metabolism during exercise in humans.The Journal of physiology · 2016Review
- Effects of an Exhaustive Exercise on Motor Skill Learning and on the Excitability of Primary Motor Cortex and Supplementary Motor Area.Medicine · 2016Observational
- Acute Modulation of Cortical Glutamate and GABA Content by Physical Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults.Sports medicine (Auckland, N.Z.) · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During and after maximal exercise there is a 15-30 % decrease in the metabolic uptake ratio (O(2)/[glucose + 1/2 lactate]) and a net lactate uptake by the human brain. This study evaluated if this cerebral metabolic uptake ratio is influenced by the intent to exercise, and whether a change could be explained by substrates other than glucose and lactate. The arterial-internal jugular venous differences (a-v difference) for O(2), glucose and lactate as well as for glutamate, glutamine, alanine, glycerol and free fatty acids were evaluated in 10 healthy human subjects in response to cycling. However, the a-v difference for the amino acids and glycerol did not change significantly, and there was only a minimal increase in the a-v difference for free fatty acids after maximal exercise. After maximal exercise the metabolic uptake ratio of the brain decreased from 6.1 +/- 0.5 (mean +/- S.E.M.) at rest to 3.7 +/- 0.2 in the first minutes of the recovery (P < 0.01). Submaximal exercise did not change the uptake ratio significantly. Yet, in a second experiment, when submaximal exercise required a maximal effort due to partial neuromuscular blockade, the ratio decreased and remained low (4.9 +/- 0.2) in the early recovery (n = 10; P < 0.05). The results indicate that glucose and lactate uptake by the brain are increased out of proportion to O(2) when the brain is activated by exhaustive exercise, and that such metabolic changes are influenced by the will to exercise. We speculate that the uptake ratio for the brain may serve as a metabolic indicator of 'central fatigue'.
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