Trial reportThe Journal of physiology2002
Postprandial hypotension in response to duodenal glucose delivery in healthy older subjects.
Trial report in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Lixisenatide on Gastric Emptying, Glycaemia and 'Postprandial' Blood Pressure in Type 2 Diabetes and Healthy Subjects.
Cardiovascular Function and Postprandial Hypotension (PPH): Effect of an Oral Glucose Load on Cardiac Contractility, Cardiac Output, Diastolic Function and Endothelial Function - Relationship to Gastric Emptying
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure.Nutrients · 2019Pooled it
- Acute GIP and GLP-1 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals.Diabetes, obesity & metabolism · 2026Trial
- A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults.BMC geriatrics · 2019Trial
- Effects of guar gum ingestion on postprandial blood pressure in older adults.The journal of nutrition, health & aging · 2015Trial
- Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.Digestive diseases and sciences · 2006Trial
- Effect of high- and low-caloric mixed liquid meals on intestinal gas dynamics.Digestive diseases and sciences · 2006Trial
- Effect of gastric distension on cardiovascular parameters: gastrovascular reflex is attenuated in the elderly.The Journal of physiology · 2004Trial
- Guar attenuates fall in postprandial blood pressure and slows gastric emptying of oral glucose in type 2 diabetes.Digestive diseases and sciences · 2003Trial
- Postprandial Hypotension in Adults: Exploring Insulin Dynamics During a Mixed Meal Test.Nutrients · 2025Article
- The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025Review
- Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients.World journal of critical care medicine · 2017Review
- Postprandial hypotension in clinical geriatric patients and healthy elderly: prevalence related to patient selection and diagnostic criteria.Journal of aging research · 2010Article
- Systemic hemodynamic changes in elderly hypertensive patients after ingesting foods with lipid, protein, and carbohydrate contents.Journal of clinical hypertension (Greenwich, Conn.) · 2009Article
- The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2008Article
- Gastric emptying after semi-solid food in multiple system atrophy and Parkinson disease.Journal of neurology · 2005Article
- Effect of aging on transpyloric flow, gastric emptying, and intragastric distribution in healthy humans--impact on glycemia.Digestive diseases and sciences · 2005Article
- Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/carbohydrate meal in type 2 diabetes.Diabetologia · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postprandial hypotension occurs frequently in older people and may lead to syncope and falls. Some recent studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is influenced by the rate of gastric emptying. The aim of this study was, therefore, to determine whether the fall in blood pressure induced by intraduodenal glucose is influenced by the rate of nutrient delivery into the small intestine, bypassing the effects of gastric emptying. Eight healthy elderly subjects (four male and four female, age 70.3 +/- 3.4 years) were studied on two separate days, in double-blind, randomised order. Glucose was infused intraduodenally at a rate of either 1 or 3 kcal min(-1), for 60 min, (0-60 min) followed by 0.9 % saline for a further 60 min (60-120 min). Blood pressure and heart rate were recorded at baseline and every 3 min during the study. Blood glucose and plasma insulin were also determined. Only the 3 kcal min(-1) infusion caused a significant fall in systolic (P < 0.001) and diastolic (P < 0.0001) blood pressure and an increase in the heart rate (P < 0.0001). The rises in blood glucose (P < 0.01) and plasma insulin (P < 0.05) concentrations were greater during the 3 kcal min(-1) infusion. We conclude that in healthy older subjects, the magnitude of the fall in blood pressure and increase in heart rate induced by intraduodenal glucose infusion is dependent on the rate of nutrient delivery into the small intestine. These results may have relevance to the treatment of postprandial hypotension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.