ArticleThe Journal of physiology2002
Evidence that ventilatory rhythmogenesis in the frog involves two distinct neuronal oscillators.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 100 citations in OpenAlex.
- The Medullary Audio-Vocal Network in the Toad Bombina orientalis.The Journal of comparative neurology · 2025Article
- Activation of respiratory-related bursting in an isolated medullary section from adult bullfrogs.The Journal of experimental biology · 2023Article
- Article
- Revisiting the two rhythm generators for respiration in lampreys.Frontiers in neuroanatomy · 2023Article
- A brainstem preparation allowing simultaneous access to respiratory motor output and cellular properties of motoneurons in American bullfrogs.The Journal of experimental biology · 2022Article
- Development of central respiratory control in anurans: The role of neurochemicals in the emergence of air-breathing and the hypoxic response.Respiratory physiology & neurobiology · 2019Review
- Buccal rhythmogenesis and CORespiratory physiology & neurobiology · 2019Article
- The rostral medulla of bullfrog tadpoles contains critical lung rhythmogenic and chemosensitive regions across metamorphosis.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- Respiratory neuron characterization reveals intrinsic bursting properties in isolated adult turtle brainstems (Trachemys scripta).Respiratory physiology & neurobiology · 2016Article
- Evolution of lung breathing from a lungless primitive vertebrate.Respiratory physiology & neurobiology · 2016Article
- Three brainstem areas involved in respiratory rhythm generation in bullfrogs.The Journal of physiology · 2015Article
- GABAergic and glycinergic inputs modulate rhythmogenic mechanisms in the lamprey respiratory network.The Journal of physiology · 2014Article
- Effects of maturation and acidosis on the chaos-like complexity of the neural respiratory output in the isolated brainstem of the tadpole, Rana esculenta.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Retrotrapezoid nucleus and parafacial respiratory group.Respiratory physiology & neurobiology · 2010Review
- Degeneracy as a substrate for respiratory regulation.Respiratory physiology & neurobiology · 2010Review
- Serotonergic modulation of respiratory rhythmogenesis and central chemoreception.Ethnicity & disease · 2010Article
- Lung respiratory rhythm and pattern generation in the bullfrog: role of neurokinin-1 and mu-opioid receptors.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2009Article
- Role of glutamate and substance P in the amphibian respiratory network during development.Respiratory physiology & neurobiology · 2008Article
- Postnatal developmental changes in activation profiles of the respiratory neuronal network in the rat ventral medulla.The Journal of physiology · 2007Article
- Looking for inspiration: new perspectives on respiratory rhythm.Nature reviews. Neuroscience · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Rana catesbeiana the upper airways are used for two distinct yet highly coordinated ventilatory behaviours: buccal ventilation and lung inflation cycles. How these behaviours are generated and coordinated is unknown. The purpose of this study was to identify putative rhythmogenic brainstem loci involved in these ventilatory behaviours. We surveyed the isolated postmetamorphic brainstem to determine sites where local depolarization, produced by microinjecting the non-NMDA glutamate receptor agonist, AMPA, augmented the ventilatory motor patterns. Two sites were identified: a caudal site, at the level of cranial nerve (CN) X, where AMPA injections caused increased buccal burst frequency but abolished lung bursts, and a rostral site, between the levels of CN VIII and IX, where injections increased the frequency of both types of ventilatory bursts. These two sites were further examined using GABA microinjections to locally inhibit cells. GABA injected into the caudal site suppressed the buccal rhythm but the lung rhythm continued, albeit at a different frequency. When GABA was injected into the rostral site the lung bursts were abolished but the buccal rhythm continued. When the two sites were physically separated by transection, both rostral and caudal brainstem sections were capable of rhythmogenesis. The results suggest the respiratory network within the amphibian brainstem is composed of at least two distinct but interacting oscillators, the buccal and lung oscillators. These putative oscillators may provide a promising experimental model for studying coupled oscillators in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.