ArticleThe Journal of physiology2002
Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre- and postsynaptic effects in the nucleus tractus solitarii.The Journal of physiology · 2024Article
- Unilateral vagotomy alters astrocyte and microglial morphology in the nucleus tractus solitarii of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Cannabidiol activation of vagal afferent neurons requires TRPA1.Journal of neurophysiology · 2020Article
- NSAIDs modulate GABA-activated currents via CaExperimental and therapeutic medicine · 2016Article
- Angiotensin II-superoxide-NFκB signaling and aortic baroreceptor dysfunction in chronic heart failure.Frontiers in neuroscience · 2015Review
- Omega-conotoxins as experimental tools and therapeutics in pain management.Marine drugs · 2013Review
- Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury.The Journal of physiology · 2013Article
- Angiotensin II-Superoxide Signaling and Arterial Baroreceptor Function in Type-1 Diabetes Mellitus.Journal of diabetes & metabolism · 2013Article
- Calcium-activated chloride current expression in axotomized sensory neurons: what for?Frontiers in molecular neuroscience · 2012Article
- International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.Pharmacological reviews · 2012Review
- Leptin amplifies the action of thyrotropin-releasing hormone in the solitary nucleus: an in vitro calcium imaging study.Brain research · 2011Article
- Ionic mechanisms underlying inflammatory mediator-induced sensitization of dural afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Influence of vagotomy on monosynaptic transmission at second-order nucleus tractus solitarius synapses.Journal of neurophysiology · 2009Article
- Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Tumor necrosis factor potentiates central vagal afferent signaling by modulating ryanodine channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Bradykinin decreases K(+) and increases Cl(-) conductances in vagal afferent neurones of the guinea pig.The Journal of physiology · 2004Article
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Authors and funding
4 authors.
Funding
Abstract
Adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) were acutely isolated 4-6 days after section of their peripheral axons (vagotomy) and examined with the whole-cell patch-clamp technique. A subset (approximately 25 %) of vagotomized NGNs displayed depolarizing after-potentials (DAPs), not present in control NGNs. DAPs were inhibited by niflumic acid (125 microM) or cadmium (100 microM), and had a reversal potential near E(Cl), indicating that they were due to Ca(2+)-activated chloride current (I(Cl(Ca))). N-type, L-type, T-/R- and other types of voltage-dependent Ca(2+) channels provided about 43, 2, 16 and 40 % of the trigger Ca(2+) for DAP generation, respectively. Intracellular Ca(2+) concentration ([Ca(2+)](i)) was estimated using fura-2 fluorescence. Resting [Ca(2+)](i) and peak [Ca(2+)](i) elevation induced by activating Ca(2+)-induced Ca(2+) release (CICR) stores with 10 mM caffeine were not significantly different among control NGNs, vagotomized NGNs with DAPs and vagotomized NGNs without DAPs, averaging 54 +/- 7.9 (n = 19; P = 0.49) and 2022 +/- 1059 nM (n = 19; P = 0.44), respectively. Blocking CICR with 10 microM ryanodine reduced DAP amplitude by approximately 37 %. Ca(2+) influx induced by action potential waveforms was increased by over 250 % in vagotomized NGNs with DAPs (19.0 +/- 2.1 pC) compared to control NGNs (5.0 +/- 0.8 pC) or vagotomized NGNs without DAPs (7.0 +/- 0.8 pC). L-type, N-type, T-/R-type and other types of Ca(2+) influx were increased proportionately in vagotomized NGNs with DAPs. In conclusion, a subset of vagotomized NGNs have increased Ca(2+) currents and express I(Cl(Ca)). These NGNs respond electrically to increases in [Ca(2+)](i) during regeneration.
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