ArticleThe Journal of experimental medicine2002
Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Immunoproteasome deficiency results in age-dependent development of epilepsy.Brain communications · 2024Article
- The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer.Archivum immunologiae et therapiae experimentalis · 2022Review
- Editorial: Targeting antigen processing and presentation in autoimmune and autoinflammatory disorders.Frontiers in immunology · 2022Article
- Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7.Oncotarget · 2017Article
- Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.PLoS genetics · 2015Article
- Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model.Translational oncology · 2014Article
- Differential expression of 26S proteasome subunits and functional activity during neonatal development.Biomolecules · 2014Article
- Self-antigen presentation by dendritic cells in autoimmunity.Frontiers in immunology · 2014Review
- Emerging roles of immunoproteasomes beyond MHC class I antigen processing.Cellular and molecular life sciences : CMLS · 2012Review
- Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.Molecular & cellular proteomics : MCP · 2012Article
- The role of the proteasome in the generation of MHC class I ligands and immune responses.Cellular and molecular life sciences : CMLS · 2011Review
- Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire.Journal of virology · 2011Article
- Expression of catalytic proteasome subunits in the gut of patients with Crohn's disease.International journal of colorectal disease · 2009Article
- Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis.The American journal of pathology · 2009Article
- Two-dimensional electrophoresis-based characterization of post-translational modifications of mammalian 20S proteasome complexes.Proteomics · 2008Article
- More than one reason to rethink the use of peptides in vaccine design.Nature reviews. Drug discovery · 2007Review
- Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.The Journal of clinical investigation · 2006Article
- BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes.Leukemia · 2006Article
- Dextran sulfate sodium-induced colitis is associated with enhanced low molecular mass polypeptide 2 (LMP2) expression and is attenuated in LMP2 knockout mice.Digestive diseases and sciences · 2006Article
- Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adoptive transfer of cross-reactive HSP60-specific CD8(+) T cells into immunodeficient mice causes autoimmune intestinal pathology restricted to the small intestine. We wondered whether local immunopathology induced by CD8(+) T cells can be explained by tissue-specific differences in proteasome-mediated processing of major histocompatibility complex class I T cell epitopes. Our experiments demonstrate that 20S proteasomes of different organs display a characteristic composition of alpha and beta chain subunits and produce distinct peptide fragments with respect to both quality and quantity. Digests of HSP60 polypeptides by 20S proteasomes show most efficient generation of the pathology related CD8(+) T cell epitope in the small intestine. Further, we demonstrate that the organ-specific potential to produce defined T cell epitopes reflects quantities that are relevant for cytotoxic T lymphocyte recognition. We propose tissue-specific antigen processing by 20S proteasomes as a potential mechanism to control organ-specific immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.