ArticleThe Journal of experimental medicine2002
Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors.JTO clinical and research reports · 2023Article
- The CD8α-PILRα interaction maintains CD8Science (New York, N.Y.) · 2022Article
- Unregulated antigen-presenting cell activation by T cells breaks self tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.eLife · 2017Article
- Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Nature immunology · 2012Article
- The role of the thymus in tolerance.Transplantation · 2010Review
- Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain.Cell death and differentiation · 2010Article
- Characterization of MHC class-I restricted TCRalphabeta+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination.Cancer immunology, immunotherapy : CII · 2009Article
- CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection.Viral immunology · 2009Article
- B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- FoxP3: a life beyond regulatory T cells.International journal of clinical and experimental pathology · 2009Article
- Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation.PloS one · 2008Article
- Mobilizing the low-avidity T cell repertoire to kill tumors.Seminars in cancer biology · 2007Review
- B7-1 mediated costimulation regulates pancreatic autoimmunity.Molecular immunology · 2007Article
- Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice.Blood · 2007Article
- CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens.The Journal of clinical investigation · 2004Article
- Antitumor activity of G3139 lipid nanoparticles (LNPs).Molecular pharmaceuticsArticle
- T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity.International reviews of immunologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A number of in vitro studies have suggested that costimulatory molecules B7-1 and B7-2 and their receptor CD28 can promote clonal deletion, and limited in vivo studies have indicated that CD28 is involved in the clonal deletion of some T cells. However, the significance of B7-mediated clonal deletion in preventing autoimmune diseases has not been studied systematically. Here we report that the perinatal blockade of B7-1 and B7-2 substantially inhibits the clonal deletion of T cells in the thymus and leads to an accumulation of T cells capable of inducing fatal multiorgan inflammation. These results reveal a critical role for costimulatory molecules B7-1 and B7-2 in deleting pathogenic autoreactive T cells in the thymus. The critical role of B7-1 and B7-2 in T cell clonal deletion may explain, at least in part, the paradoxical increase of autoimmune disease in mice deficient for this family of costimulatory molecules, such as cytotoxic T lymphocyte associated molecule 4, CD28, and B7-2. The strong pathogenicity of the self-reactive T cells supports a central hypothesis in immunology, which is that clonal deletion plays an important role in preventing autoimmune diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.