ArticleThe Journal of cell biology2002
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 82 citations in OpenAlex.
- Targeting the CD47-SIRPα Axis in Atherosclerosis: From Pathogenesis to Therapeutic Implications.Journal of inflammation research · 2026Review
- Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction.Frontiers in cell and developmental biology · 2020Article
- Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains.Journal of cell science · 2019Article
- PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8Journal for immunotherapy of cancer · 2019Article
- Unraveling the role of membrane microdomains during microbial infections.Cell biology and toxicology · 2017Review
- CD99-Derived Agonist Ligands Inhibit Fibronectin-Induced Activation of β1 Integrin through the Protein Kinase A/SHP2/Extracellular Signal-Regulated Kinase/PTPN12/Focal Adhesion Kinase Signaling Pathway.Molecular and cellular biology · 2017Article
- EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells.Cancer research · 2016Article
- Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2.BMB reports · 2015Article
- The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.Molecular cancer research : MCR · 2013Article
- Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.Nature immunology · 2013Article
- The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.Molecular biology of the cell · 2012Article
- Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles.Virology · 2012Article
- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes.Experimental & molecular medicine · 2011Article
- Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol.PLoS pathogens · 2011Article
- The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection.Frontiers in microbiology · 2011Article
- Influence of hydrophobic mismatch and amino acid composition on the lateral diffusion of transmembrane peptides.Biophysical journal · 2010Article
- Phosphorylation of leukocyte PECAM and its association with detergent-resistant membranes regulate transendothelial migration.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways.PloS one · 2010Article
- SHP-2 expression negatively regulates NK cell function.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell signaling does not occur randomly over the cell surface, but is integrated within cholesterol-enriched membrane domains, termed rafts. By targeting SHP-2 to raft domains or to a non-raft plasma membrane fraction, we studied the functional role of rafts in signaling. Serum-depleted, nonattached cells expressing the raft SHP-2 form, but not non-raft SHP-2, display signaling events resembling those observed after fibronectin attachment, such as beta1 integrin clustering, 397Y-FAK phosphorylation, and ERK activation, and also increases Rho-GTP levels. Expression of the dominant negative N19Rho abrogates raft-SHP-2-induced signaling, suggesting that Rho activation is a downstream event in SHP-2 signaling. Expression of a catalytic inactive SHP-2 mutant abrogates the adhesion-induced feedback inhibition of Rho activity, suggesting that SHP-2 contributes to adhesion-induced suppression of Rho activity. Because raft recruitment of SHP-2 occurs physiologically after cell attachment, these results provide a mechanism by which SHP-2 may influence cell adhesion and migration by spatially regulating Rho activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.