ArticleThe Journal of cell biology2002
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
94 citing papers in PubMed, 242 citations in OpenAlex.
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- Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina.Communications biology · 2023Article
- Unleashing Intrinsic Growth Pathways in Regenerating Peripheral Neurons.International journal of molecular sciences · 2022Review
- The Nogo-66 Receptors NgR1 and NgR3 Are Required for Commissural Axon Pathfinding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons.Cellular and molecular neurobiology · 2021Article
- Neurobiological Opportunities in Diabetic Polyneuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.Developmental cell · 2021Article
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- Semaphorins in Adult Nervous System Plasticity and Disease.Frontiers in synaptic neuroscience · 2021Review
- Genome-Wide Association Study of Body Shape-Related Traits in Large Yellow Croaker (Larimichthys crocea).Marine biotechnology (New York, N.Y.) · 2020Article
- Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.Diabetes · 2020Article
- Modulation of Sensory Nerve Function by Insulin: Possible Relevance to Pain, Inflammation and Axon Growth.International journal of molecular sciences · 2020Review
- How scars shape the neural landscape: Key molecular mediators of TGF-β1's anti-neuritogenic effects.PloS one · 2020Article
- PTEN in Autism and Neurodevelopmental Disorders.Cold Spring Harbor perspectives in medicine · 2019Review
- Effects of siRNA-Mediated Knockdown of GSK3β on Retinal Ganglion Cell Survival and Neurite/Axon Growth.Cells · 2019Article
- MicroRNA-30b regulates the polarity of retinal ganglion cells by inhibiting semaphorin-3A.Molecular vision · 2019Article
- Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.Nature communications · 2018Article
- Insulin Confers Differing Effects on Neurite Outgrowth in Separate Populations of Cultured Dorsal Root Ganglion Neurons: The Role of the Insulin Receptor.Frontiers in neuroscience · 2018Article
- A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.Development (Cambridge, England) · 2017Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in several aspects in embryonic development and several growth factor signaling cascades. We now report that an inactive phosphorylated pool of the enzyme colocalizes with F-actin in both neuronal and nonneuronal cells. Semaphorin 3A (Sema 3A), a molecule that inhibits axonal growth, activates GSK-3 at the leading edge of neuronal growth cones and in Sema 3A-responsive human breast cancer cells, suggesting that GSK-3 activity might play a role in coupling Sema 3A signaling to changes in cell motility. We show that three different GSK-3 antagonists (LiCl, SB-216763, and SB-415286) can inhibit the growth cone collapse response induced by Sema 3A. These studies reveal a novel compartmentalization of inactive GSK-3 in cells and demonstrate for the first time a requirement for GSK-3 activity in the Sema 3A signal transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.