ArticleBritish journal of cancer2002
An infectious aetiology for childhood brain tumours? Evidence from space-time clustering and seasonality analyses.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Space-time clustering of childhood cancers: a systematic review and pooled analysis.European journal of epidemiology · 2019Pooled it
- Article
- High parental occupational social contact and risk of childhood hematopoietic, brain and bone cancers.Cancer epidemiology · 2019Article
- Childhood cancer in small geographical areas and proximity to air-polluting industries.Environmental research · 2017Article
- Spatial analysis of childhood cancer: a case/control study.PloS one · 2015Article
- Population mixing for leukaemia, lymphoma and CNS tumours in teenagers and young adults in England, 1996-2005.BMC cancer · 2014Article
- UK case control study of brain tumours in children, teenagers and young adults: a pilot study.BMC research notes · 2014Article
- Cross-space-time clustering of childhood cancer in Great Britain: evidence for a common aetiology.International journal of cancer · 2014Article
- Case-control study of paternal occupation and social class with risk of childhood central nervous system tumours in Great Britain, 1962-2006.British journal of cancer · 2013Article
- Space-time clustering of childhood central nervous system tumours in Yorkshire, UK.BMC cancer · 2012Article
- Space-time clustering in childhood nervous system tumors in the Region of Murcia, Spain, 1998-2009.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture, Japan.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Knox meets Cox: adapting epidemiological space-time statistics to demographic studies.Demography · 2010Article
- The association between birth order, sibship size and glioma development in adulthood.International journal of cancer · 2010Article
- Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth.British journal of cancer · 2010Article
- Season of birth and risk for adult onset glioma.International journal of environmental research and public health · 2010Review
- Seasonality of birth in children with central nervous system tumours in Denmark, 1970-2003.British journal of cancer · 2009Article
- Potential mechanisms of the human polyomavirus JC in neural oncogenesis.Journal of neuropathology and experimental neurology · 2008Review
- A method to model season of birth as a surrogate environmental risk factor for disease.International journal of environmental research and public health · 2008Article
- Breastfeeding and risk of childhood CNS tumours.British journal of cancer · 2007Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space-time clustering and seasonality using population-based data from the North West of England for the period 1954 to 1998. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km, and close in time, <1 year apart. Addresses at birth and diagnosis were used. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. Tests for heterogeneity and Edwards' test for sinusoidal variation were applied to examine changes of incidence with month of birth or diagnosis. There was strong evidence of space-time clustering, particularly involving cases of astrocytoma and ependymoma. Analyses of seasonal variation showed excesses of cases born in the late Autumn or Winter. Results are consistent with a role for infections in a proportion of cases from these diagnostic groups. Further studies are needed to identify putative infectious agents.
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