ArticleInfection and immunity2002
Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
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- Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study.Clinical kidney journal · 2021Article
- Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.Clinical kidney journal · 2021Article
- Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2021Article
- Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and InflammationFrontiers in immunology · 2020Article
- Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study.Endocrine connections · 2019Article
- Serum uromodulin-a marker of kidney function and renal parenchymal integrity.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis.Molecules (Basel, Switzerland) · 2017Article
- From juvenile hyperuricaemia to dysfunctional uromodulin: an ongoing metamorphosis.Pediatric nephrology (Berlin, Germany) · 2016Review
- A Preliminary Study Into the Significance of Intrarenal Reflux in BK Virus Nephropathy After Kidney Transplantation.Transplantation direct · 2016Article
- Single-nucleotide polymorphism of theBiomedical reports · 2015Article
- Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.American journal of physiology. Renal physiology · 2013Review
- Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels.Kidney international · 2013Article
- Urinary uromodulin excretion predicts progression of chronic kidney disease resulting from IgA nephropathy.PloS one · 2013Article
- Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap.The Journal of biological chemistry · 2012Article
- Uromodulin in kidney injury: an instigator, bystander, or protector?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012Review
- Recent advances in the pathogenesis and management of cast nephropathy (myeloma kidney).Bone marrow research · 2011Article
- Abnormal expression and processing of uromodulin in Fabry disease reflects tubular cell storage alteration and is reversible by enzyme replacement therapy.Journal of inherited metabolic disease · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In renal bacterial infections granulocytes are of major importance in the primary immune defense against invading pathogens. However, the mechanisms of granulocytic activation in renal interstitial invasion have not been clarified. Renal tubular epithelial cell mechanisms inducing granulocytic activation and bacterial killing may include tubular cell expression of Tamm-Horsfall protein (THP), a urinary protein that is known to enhance cytokine expression in monocytes. We studied the role of THP in granulocytic activation. A strong binding of THP to human granulocytes was demonstrated by fluorescence-activated cell sorter analysis. Urinary THP and supernatants of THP-expressing cultured tubular epithelial cells (MDCK) enhanced interleukin-8 (IL-8) expression by human granulocytes. Renal tubular cells growing polarized on polycarbonate membranes were used to study apical versus basal THP expression. By electron microscopy THP immunoreactivity was exclusively found on the apical surfaces of tubular cells and was absent on the basolateral cell membrane. In the apical cell culture compartment we found significantly more stimulatory activity for granulocytic IL-8 expression. CD62L, a selectin less expressed in activated granulocytes, was decreased in granulocytes incubated with urinary THP and in supernatants of THP-producing renal tubular cells but not in supernatants from THP-negative cells. Again, the effect on CD62L expression was found only in apical culture media and was absent in the basal compartment. In summary our data give evidence that renal tubular cell THP expression may be relevant in kidney diseases since THP is a potent activator of human granulocytes. The regulation of apical versus basal THP expression and release in vivo may be crucial in the induction of the inflammatory response, e.g., in bacterial renal diseases.
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