ArticleInfection and immunity2002
Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Control ofMicrobiology spectrum · 2023Article
- Analysis of gastric microbiome reveals three distinctive microbial communities associated with the occurrence of gastric cancer.BMC microbiology · 2022Article
- The immune microenvironment in gastric adenocarcinoma.Nature reviews. Gastroenterology & hepatology · 2022Review
- Role of Gastric Microorganisms Other thanBioMed research international · 2022Review
- Isolation of lymphocytes from the human gastric mucosa.World journal of methodology · 2021Review
- Gut Fecal Microbiota Transplant in a Mouse Model of Orthotopic Rectal Cancer.Frontiers in oncology · 2020Article
- Changes of the Gastric Mucosal Microbiome Associated With Histological Stages of Gastric Carcinogenesis.Frontiers in microbiology · 2020Article
- Epizootiological characteristics of viable bacteria and fungi in indoor air from porcine, chicken, or bovine husbandry confinement buildings.Journal of veterinary science · 2016Article
- Gastrointestinal malignancy and the microbiome.Gastroenterology · 2014Review
- Article
- Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases.World journal of gastroenterology · 2012Article
- Helicobacter felis--associated gastric disease in microbiota-restricted mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.Gastroenterology · 2011Article
- Helicobacter pylori and gastric cancer: factors that modulate disease risk.Clinical microbiology reviews · 2010Review
- Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements.Helicobacter · 2010Article
- Role of innate immunity in Helicobacter pylori-induced gastric malignancy.Physiological reviews · 2010Review
- Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice.Gastroenterology · 2010Article
- Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice.The American journal of pathology · 2009Article
- Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.Cancer research · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In mouse models and humans, Helicobacter pylori is associated with an increase in serum gastrin and gastrin-expressing (G) cells with a concomitant decrease in somatostatin-expressing D cells. Inflammation of the gastric mucosa can progress to metaplastic changes in the stomach and to decreased colonization by H. pylori and increased colonization by non-H. pylori organisms. In addition, about 20% of individuals with chronic gastritis are H. pylori negative, suggesting that other organisms may induce gastritis. Consistent with this hypothesis, we report here that Acinetobacter lwoffii causes the same histologic changes as does H. pylori. Gastric epithelial cells were isolated from the entire stomach by an enzymatic method for quantitation by both flow cytometry and morphometric analysis. Two months after mice were inoculated with H. pylori or A. lwoffii, the mucosal T- and B-cell numbers significantly increased. After 4 months of infection, there was a threefold increase in the number of G cells and a doubling in the number of parietal cells. A threefold decrease in the number of D cells occurred in H. pylori- and A. lwoffii-infected mice. Plasma gastrin levels increased after both H. pylori and A. lwoffii infection. Histology revealed the presence of inflammation in the gastric mucosa with both A. lwoffii and H. pylori infection. A periodic acid-Schiff stain-alcian blue stain revealed mucous gland metaplasia of the corpus. Collectively, the results demonstrate that gastritis and hypergastrinemia are not specific for H. pylori but can be induced by other gram-negative bacteria capable of infecting the mouse stomach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.